Adenosine Use in Emergency Heart Rate Management - Cardiology

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Hello, Doctor.
I apologize for asking you a question.
The other day, I went to the emergency room with a heart rate of 180, but there was no evidence of PSVT.
Does that mean I likely do not have PSVT? Additionally, I would like to ask if the doctors administered adenosine twice that day despite the absence of PSVT—could that have any effects on my body? I read online that after administering adenosine, the heart often experiences a sudden drop, and patients need to cough to recover.
However, I did not experience this; I only felt chest tightness when the adenosine was administered.
Is it possible that the medication was ineffective because it was not PSVT? If there is no PSVT, what potential issues could arise from administering adenosine? Does adenosine remain in the body, or is it metabolized within a day? I apologize for asking so many questions, but I am really anxious.
Thank you, Doctor, and I hope you are well.

Niming, 20~29 year old female. Ask Date: 2023/06/07

Dr. He Dongjin reply Cardiology


Hello, ADENOSINE has a very short duration of action; it is metabolized within minutes and does not remain in the body, so it will not cause any issues.
There's no need to worry.
Changhua Hospital cares about you.

Reply Date: 2023/06/07

More Info


Adenosine is a medication commonly used in emergency settings to manage certain types of rapid heart rates, particularly paroxysmal supraventricular tachycardia (PSVT). It works by temporarily blocking the electrical signals in the heart, which can help restore a normal heart rhythm. However, it is important to understand its use, effects, and potential side effects, especially in cases where PSVT is not present.

In your situation, where your heart rate reached 180 beats per minute but PSVT was not diagnosed, it is essential to clarify that not all rapid heart rates are due to PSVT. Other conditions, such as atrial fibrillation or other forms of tachycardia, can also cause elevated heart rates. The absence of PSVT means that the specific mechanism that adenosine targets may not have been present, which could explain why you did not experience the typical response (such as a sudden drop in heart rate followed by the need to cough).

When adenosine is administered, it can cause a brief and dramatic decrease in heart rate, often leading to a sensation of lightheadedness or chest discomfort. This is due to its rapid action and the way it affects the heart's conduction system. If you felt chest tightness but did not experience the typical "crash" response, it may indicate that your heart rhythm was not responsive to adenosine, possibly due to the underlying cause of your tachycardia not being PSVT.

Regarding the safety of adenosine when PSVT is not present, it is generally considered safe. Adenosine is rapidly metabolized by the body, with a half-life of less than 10 seconds, meaning it does not remain in the system for long periods. It is unlikely to cause any long-term effects or complications when used appropriately, even if the specific arrhythmia being treated is not present.

As for your concerns about side effects, adenosine can cause transient side effects such as flushing, chest discomfort, shortness of breath, or a feeling of impending doom. These effects are usually brief and resolve quickly after the medication is metabolized. It is important to communicate any discomfort you experience during treatment to the medical staff, as they can provide reassurance and monitor your condition.

In summary, while adenosine is a valuable tool in managing certain types of tachycardia, its use in cases where PSVT is not present may not yield the expected results. However, it is generally safe and does not have lasting effects on the body. If you continue to experience episodes of rapid heart rate, it is crucial to follow up with your healthcare provider for further evaluation and management. They may consider additional diagnostic tests or alternative treatments based on your specific condition and medical history. Remember, managing anxiety and stress is also an important part of your overall heart health, so consider discussing these feelings with your doctor as well.

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