Managing Ulcerative Colitis During COVID-19: Treatment Options and Concerns - Gastroenterology and Hepatology

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Ulcerative Colitis


Hello doctor, I was diagnosed with ulcerative colitis last May, which was mild to moderate and treated with steroids (2 tablets a day) and anti-inflammatory medication (2 tablets a day).
In May of this year, a colonoscopy showed that the intestinal mucosa had healed.
Currently, I am taking anti-inflammatory medication (1 tablet every 2 days) for maintenance.
This weekend, I developed cold symptoms and tested positive for COVID-19 (first diagnosis).
However, this morning I experienced abdominal pain and diarrhea twice.
I am concerned that the COVID-19 infection may trigger a relapse of my ulcerative colitis.
Can I use steroids again for treatment (either 2 oral tablets of steroids or steroid enemas)? What should I do?

Guang, 40~49 year old female. Ask Date: 2023/06/15

Dr. Chen Shidian reply Gastroenterology and Hepatology


There may be interactions or unrelated factors; once the virus tests negative, a follow-up appointment with the physician can be scheduled to discuss further examinations.
Continue medication as prescribed.

Reply Date: 2023/06/15

More Info


Managing ulcerative colitis (UC) during the COVID-19 pandemic presents unique challenges, particularly when a patient experiences a new COVID-19 infection alongside their existing gastrointestinal condition. Your situation, where you have a history of UC and are currently experiencing symptoms after testing positive for COVID-19, requires careful consideration of treatment options and potential risks.

Firstly, it is essential to understand that ulcerative colitis is an inflammatory bowel disease characterized by chronic inflammation of the colon. Patients with UC often require medications such as corticosteroids and anti-inflammatory drugs to manage their symptoms and maintain remission. In your case, you have been successfully managing your UC with a regimen that includes steroids and anti-inflammatory medications, and your recent colonoscopy showed improvement in your intestinal mucosa.

Now, regarding your current situation with COVID-19 and the onset of abdominal pain and diarrhea, it is crucial to differentiate between symptoms that may be related to COVID-19 and those that could indicate a flare-up of ulcerative colitis. COVID-19 can cause gastrointestinal symptoms, including diarrhea, which may mimic or exacerbate UC symptoms. Therefore, it is important to monitor your symptoms closely.

In terms of treatment, the use of corticosteroids during a COVID-19 infection is a nuanced decision. Corticosteroids can suppress the immune response, which may be a concern in the context of a viral infection like COVID-19. However, if you are experiencing a flare-up of your ulcerative colitis, the benefits of using corticosteroids to control inflammation may outweigh the risks. It is generally recommended to use the lowest effective dose of corticosteroids for the shortest duration necessary to manage your symptoms.

Here are some considerations for your situation:
1. Consult Your Gastroenterologist: Before making any changes to your medication regimen, it is crucial to consult with your gastroenterologist or healthcare provider. They can assess your current symptoms, review your medical history, and provide personalized recommendations based on the latest clinical guidelines.

2. Monitor Symptoms: Keep a detailed record of your symptoms, including the frequency and severity of abdominal pain and diarrhea. This information will be helpful for your healthcare provider in determining the best course of action.

3. Consider Symptomatic Treatment: If your symptoms are mild and manageable, your healthcare provider may recommend symptomatic treatment, such as hydration and dietary adjustments, rather than immediately resorting to corticosteroids.

4. Risk Assessment: Your healthcare provider will assess the risks associated with using corticosteroids during a COVID-19 infection. If your symptoms suggest a significant flare-up of UC, they may recommend a short course of corticosteroids, either orally or as an enema, depending on the severity and location of your symptoms.

5. Follow COVID-19 Guidelines: Ensure that you are following public health guidelines regarding COVID-19, including isolation and monitoring for any worsening symptoms. If you experience severe symptoms such as difficulty breathing or persistent chest pain, seek medical attention immediately.

6. Long-term Management: Once you recover from COVID-19, it will be important to continue monitoring your ulcerative colitis and follow up with your gastroenterologist to adjust your treatment plan as needed.

In conclusion, managing ulcerative colitis during a COVID-19 infection requires a careful and individualized approach. While corticosteroids may be necessary to control UC symptoms, their use should be guided by a healthcare professional who can weigh the potential risks and benefits in the context of your overall health. Always prioritize open communication with your healthcare team to ensure the best possible outcomes for both your ulcerative colitis and your COVID-19 recovery.

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