Heart Rhythm Disorders Linked to Depression and Bipolar Disorder - Cardiology

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Depression, bipolar disorder, and arrhythmia?


I apologize for bothering you, Director.
May I ask if arrhythmias caused by autonomic nervous system dysfunction are normal and pose no life-threatening risk? Recently, I have been experiencing increased panic and anxiety.
The doctor mentioned that it resembles the depressive phase of bipolar disorder.
I came across this statement: "Depression is a brain disorder, specifically involving issues in the brain, particularly the prefrontal cortex, which is also the control center for the parasympathetic nervous system.
This dysfunction can lead to problems in the parasympathetic nervous system, which, in a heart that is more sensitive, can result in an inability to regulate heart rate.
Therefore, patients may be at risk of death from arrhythmias, which is a significant reason why individuals with depression and bipolar disorder may die from cardiovascular diseases." This has been worrying me, especially since I experience around 100 VPCs and APCs a day, and lately, my heart rate has been increasing.
In the morning, after taking antiarrhythmic medication, my heart rate can still reach around 130 after walking, and when I panic, it can spike to 180 without PSVT.
Director, could this also be related to the inability of the parasympathetic nervous system to control heart rate, or is my heart too sensitive? Does this mean it is very dangerous? Given that my depression, anxiety, and bipolar symptoms can easily manifest in my heart rate, is there a significant risk of fatal arrhythmias? I apologize for troubling you, and I am truly worried.
Thank you very much.

Niming, 20~29 year old female. Ask Date: 2023/06/24

Dr. He Dongjin reply Cardiology


Hello, stop searching for information online.
If you want to scare yourself, keep looking.
There are many sensational claims on the internet.
Experiencing a hundred or so palpitations a day is really not that uncommon, and it's not easy to be in serious danger.
Please stop frightening yourself.
Changhua Hospital cares about you.

Reply Date: 2023/06/24

More Info


Understanding the connection between heart rhythm disorders and mental health conditions such as depression and bipolar disorder is crucial for both patients and healthcare providers. The interplay between the autonomic nervous system, particularly the parasympathetic nervous system, and heart function can lead to significant concerns, especially when anxiety and mood disorders are involved.

Firstly, it’s important to clarify that heart rhythm disorders, including premature ventricular contractions (PVCs) and premature atrial contractions (PACs), are common and often benign in individuals without underlying heart disease. Your Holter monitor results indicate that while you experience these arrhythmias, there are no significant abnormalities in your heart's structure or function. The average heart rate you reported, along with the absence of serious arrhythmias like atrial fibrillation or ventricular tachycardia, suggests that your heart is functioning normally despite the occasional irregular beats.

The concern you raised regarding the potential dangers of heart rhythm disorders in the context of depression and bipolar disorder is valid. Research has shown that individuals with mood disorders may have an increased risk of cardiovascular diseases, including arrhythmias. This is partly due to the effects of stress and anxiety on the autonomic nervous system, which regulates heart rate and rhythm. When the body is under stress, the sympathetic nervous system (the "fight or flight" response) can become overactive, leading to increased heart rates and potential arrhythmias. Conversely, the parasympathetic nervous system, which helps to calm the body, may not function optimally in individuals with mood disorders, further complicating heart rate regulation.

Your experience of panic and anxiety, particularly with episodes of rapid heart rate, is not uncommon among individuals with anxiety disorders. The sensation of your heart racing can be distressing and may exacerbate feelings of panic, creating a vicious cycle. It’s essential to understand that while these symptoms can be alarming, they do not necessarily indicate a life-threatening condition, especially given your normal cardiac evaluations.

In terms of management, it is crucial to address both the psychological and physiological aspects of your symptoms. Cognitive-behavioral therapy (CBT) and other forms of psychotherapy can be effective in managing anxiety and panic symptoms. Additionally, medication management, including the use of SSRIs (selective serotonin reuptake inhibitors) like sertraline, can help stabilize mood and reduce anxiety, which may, in turn, alleviate some of the physical symptoms you are experiencing.

Regarding your concerns about the potential for life-threatening arrhythmias due to your mental health conditions, it is reassuring to note that while there is a correlation between mood disorders and cardiovascular risks, the actual incidence of fatal arrhythmias in individuals without significant heart disease is low. However, ongoing communication with your healthcare providers is essential. Regular follow-ups with both your psychiatrist and cardiologist can help ensure that your mental health and heart health are being monitored and managed effectively.

In conclusion, while your symptoms are understandably concerning, they are not uncommon in the context of anxiety and mood disorders. With appropriate treatment and support, both your mental health and heart rhythm can be managed effectively. It is vital to continue discussing your symptoms with your healthcare providers, who can help tailor a treatment plan that addresses both your psychological and physiological needs. Remember, you are not alone in this, and there are effective strategies to help you cope with and manage your symptoms.

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Related FAQ

Bipolar Disorder

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