Does Taking Antidepressants Affect the Efficacy of Birth Control Pills? - Obstetrics and Gynecology

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Hello, doctor.
I have been taking the oral contraceptive pill (Yaz) for a month, and I usually take a medication called Duphaston.
Will this affect the contraceptive effect? How many hours should I wait before taking them? Also, I have experienced bleeding after my period while taking Yaz, and the day after I finish the 21-day course, the bleeding increases.
Should I stop taking the pill?

Sun, 10~19 year old female. Ask Date: 2023/07/04

Dr. Lin Manying reply Obstetrics and Gynecology


Hello, Sun: The medication Diurol will not affect the effectiveness of contraceptives.
It is recommended to take birth control pills before bedtime, and to avoid taking them with other medications for two hours.
If you experience increased bleeding the day after stopping the medication, there is no need to discontinue it.
The Hualien Hospital of the Ministry of Health and Welfare cares about you.

Reply Date: 2023/07/04

More Info


When considering the interaction between antidepressants and birth control pills, it's essential to understand how these medications can affect each other. Antidepressants, particularly certain types, can potentially influence the efficacy of hormonal contraceptives, including birth control pills like "Yaz" (referred to as 悅己 in your question).
Firstly, it's important to note that not all antidepressants have the same effect on birth control pills. Some antidepressants, particularly those that are enzyme inducers (like certain medications in the class of anticonvulsants), can lower the effectiveness of hormonal contraceptives by increasing the metabolism of the hormones in the birth control pills. This means that if you are taking an antidepressant that induces liver enzymes, it could potentially reduce the contraceptive effectiveness, leading to an increased risk of unintended pregnancy.

On the other hand, most selective serotonin reuptake inhibitors (SSRIs), such as "Zoloft" (sertraline), do not significantly affect the efficacy of birth control pills. Studies have shown that SSRIs generally do not interfere with the hormonal mechanisms of birth control pills, making them a safer choice for women who are concerned about maintaining effective contraception while managing depression or anxiety.

Regarding the timing of taking these medications, it is generally recommended to take them at the same time each day to maintain consistent hormone levels in your body. However, there is no specific requirement to space them out by several hours. The key is to establish a routine that works for you, ensuring that you take both the antidepressant and the birth control pill consistently.

As for the bleeding you are experiencing after stopping the birth control pill, it is not uncommon for women to experience changes in their menstrual cycle when starting or stopping hormonal contraceptives. Breakthrough bleeding or spotting can occur, especially during the first few months of use or after stopping the pill. If the bleeding is heavy or accompanied by severe pain, it is advisable to consult with your healthcare provider to rule out any underlying issues and to discuss whether you should continue or adjust your birth control method.

In summary, while certain antidepressants can affect the efficacy of birth control pills, many commonly prescribed SSRIs do not have a significant impact. It is crucial to maintain a consistent routine for taking both medications and to monitor any changes in your menstrual cycle. If you have concerns about bleeding or the effectiveness of your birth control, discussing these with your healthcare provider is essential for personalized advice and management.

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