Tiny Acute Ischemic Infarcts: Causes and Management - Neurology

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Physical examination revealed signs of a previous minor stroke?


Hello Doctor: Last month, the MRI results for my brain were interpreted as follows: Z719 Counseling, unspecified, V6540 Counseling, not otherwise specified, ||cre:0, eGFRr:0 Imaging findings: Brain MRI study without Gd-DTPA enhancement showed: - A tiny bright signal intensity in the left occipital subcortical white matter on FLAIR and DWI (IMA: 96), and dark signal intensity in the same areas on ADC, compatible with an acute ischemic infarct.
- Consistent ventricular size with brain volume.
- No evidence of intracranial hemorrhage or space-occupying lesion.
- MRA: suspect focal stenosis at the inferior branch of the right MCA.
Impression: A tiny acute ischemic infarct in the left occipital subcortical region.

Carotid ultrasound:
Right side:
ECA1: Diameter 3.8 mm, PSV/EDV 98/27, Rl 0.72, Flow 167
ICA1: Diameter 4.3 mm, PSV/EDV 97/47, Rl 0.51, Flow 354
CCA1: Diameter 6.0 mm, PSV/EDV 110/35, Rl 0.68, Flow 606
C5-C4: Diameter 3.6 mm, PSV/EDV 54/26, Rl 0.52, Flow 130
B-Model: 3.7
Left side:
ECA1: Diameter 3.5 mm, PSV/EDV 113/25, Rl 0.78, Flow 154
ICA1: Diameter 4.6 mm, PSV/EDV 89/43, Rl 0.52, Flow 323
CCA1: Diameter 6.0 mm, PSV/EDV 112/39, Rl 0.65, Flow 579
C5-C4: Diameter 3.1 mm, PSV/EDV 64/25, Rl 0.61, Flow 89
B-Model: 3.2
Intracranial ultrasound:
RMLS: 87.5 mm, 3rd Ventricle R: 93.7 mm, L: 93.7 mm, LMLS: 87.5 mm
Right side:
Dept S/D Mean Pl
MCA1: 65, 102/48, 66, 0.83
MCA2: 59, 104/50, 68, 0.79
MCA3: 53, 54/27, 36, 0.76
ACA1: 72, -92/-45, -60, 0.78
PCA1: 77, 69/36, 47, 0.70
VA1: 58, -41/-23, -29, 0.61
Left side:
Dept S/D Mean Pl
MCA1: 62, 108/52, 71, 0.79
MCA2: 54, 114/61, 79, 0.68
MCA3: 44, 41/21, 28, 0.70
ACA1: 74, -67/-38, -48, 0.60
PCA1: 75, 68/34, 46, 0.73
VA1: 56, -43/-23, -30, 0.67
TCCS:
Dept S/D Mean Pl
BA1: 90, -63/-35, -44, 0.63
BA2: 99, -74/-41, -52, 0.62
BA3: 105, 76/41, 53, 0.68
Blood tests for hyperlipidemia have all been checked and are currently within normal limits.
Cardiac evaluations including a 24-hour Holter monitor and echocardiogram are normal.
The doctor is uncertain about the factors leading to the small stroke, suggesting that external factors could also be a possibility.
I recall having a head injury from a car accident 30 years ago, which caused headaches for a while, and was described by elders as a concussion.
Could this have any related effects?
Additionally, I would like to ask if the medication prescribed for three months needs to be taken for life? Should I also consider additional dietary supplements? Currently, I am 174 cm tall and weigh 92-93 kg.
The doctor mentioned that obesity could have an impact, and I am actively working on losing weight.

Pao Mo Lu Cha, 30~39 year old female. Ask Date: 2023/07/14

Dr. Jiang Junyi reply Neurology


Hello, sir: You mentioned "A tiny acute ischemic infarct, left occipital subcortical white." An elder relayed that it was a concussion; could this have related effects? MRI primarily detects cerebral infarctions within a month.
It cannot explain events that occurred much earlier.
The hospital prescribed Berkey for three months and scheduled a follow-up; does this medication need to be taken for life? Additionally, should I supplement with any health products? Medication can relatively reduce the risk of thrombosis, but it is not a permanent solution.
It is crucial to control all risk factors for cerebrovascular diseases, such as diabetes, hypertension, smoking, hyperlipidemia, and sleep apnea, among others.
Prolonged exposure to these risk factors can lead to atherosclerosis, increasing the likelihood of cerebrovascular and cardiovascular diseases.
Given your age, screening for young-onset stroke, such as autoimmune diseases, is typically conducted.
I recommend discussing examinations and treatments with your neurologist.
Thank you for your inquiry.
If you have further questions, feel free to discuss.
Wishing you good health, peace, and happiness.
Dr.
Jiang Junyi, Department of Neurology, Taoyuan Hospital, cares for you.

Reply Date: 2023/07/14

More Info


Understanding tiny acute ischemic infarcts is crucial for effective management and prevention of future cerebrovascular events. Your recent MRI findings indicate a tiny acute ischemic infarct in the left occipital subcortical white matter, which is a significant concern, even if it is small. The presence of such an infarct suggests that there has been a temporary disruption in blood flow to that area of the brain, which can lead to neurological deficits depending on the extent and location of the infarct.


Causes of Acute Ischemic Infarcts
Acute ischemic infarcts can arise from various causes, including:
1. Embolism: This occurs when a blood clot or debris travels from another part of the body (often the heart) and lodges in a cerebral artery, blocking blood flow.

2. Thrombosis: A clot forms in the artery itself, often due to atherosclerosis, where plaque builds up in the arteries, narrowing them and potentially leading to clot formation.

3. Hypoperfusion: This can occur due to systemic factors that reduce blood flow, such as severe hypotension or heart failure.

4. Vascular Stenosis: As noted in your MRA findings, focal stenosis in the inferior branch of the right middle cerebral artery (MCA) could contribute to reduced blood flow, increasing the risk of ischemic events.


Management of Acute Ischemic Infarcts
Management typically involves both acute and long-term strategies:
1. Acute Management: If an ischemic stroke is suspected, immediate medical attention is critical. Treatments may include thrombolytics (clot busters) if the patient presents within a specific time frame from symptom onset. However, given that your infarct is already identified, the focus will be on preventing further events.

2. Antiplatelet Therapy: Medications like aspirin or clopidogrel are often prescribed to prevent further clot formation. You mentioned being prescribed "伯基" (likely referring to clopidogrel), which is commonly used for this purpose. The duration of antiplatelet therapy can vary based on individual risk factors, but many patients remain on these medications long-term, especially after an ischemic event.

3. Management of Risk Factors: It's essential to control any underlying conditions that may contribute to stroke risk, such as hypertension, diabetes, and hyperlipidemia. Regular monitoring and lifestyle modifications, including diet and exercise, are crucial. Given your weight and efforts to lose weight, this is an excellent step towards reducing your stroke risk.

4. Lifestyle Modifications: Maintaining a healthy weight, engaging in regular physical activity, and following a heart-healthy diet (such as the Mediterranean diet) can significantly reduce the risk of future strokes. Avoiding smoking and limiting alcohol intake are also important.

5. Follow-Up Care: Regular follow-up appointments with your healthcare provider are essential to monitor your condition and adjust medications as necessary. Your doctor may also recommend additional imaging studies or tests to assess the status of your cerebral circulation.


Potential Impact of Past Trauma
Regarding your history of head trauma from a car accident, it is possible that previous injuries could have long-term effects on brain health. Traumatic brain injuries (TBIs) can lead to changes in blood flow and increase the risk of cerebrovascular diseases later in life. However, the exact relationship between past trauma and your current ischemic event would require further evaluation by a neurologist.


Conclusion
In summary, tiny acute ischemic infarcts, while small, should not be underestimated. They indicate underlying vascular issues that need to be addressed through a combination of medication, lifestyle changes, and regular medical follow-up. Your current medication regimen, including antiplatelet therapy, is likely appropriate, but ongoing assessment is crucial. Additionally, maintaining a healthy lifestyle and managing risk factors will be key in preventing future strokes. Always consult your healthcare provider for personalized advice and treatment plans tailored to your specific health needs.

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