Can Zinc Supplements Help with Appetite Issues in Epilepsy Patients? - Neurology

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Zinc for epilepsy medication?


Dear Doctor: I usually take Lamictal due to a diagnosis of poor appetite.
Can I supplement with zinc? Some articles mention that excessive zinc should be avoided in epilepsy.
Since there is still some time until my next appointment, I would like to ask you here.
Thank you for your response.

Xi Xi, 40~49 year old female. Ask Date: 2023/07/27

Dr. Cai Zongzhang reply Neurology


Hello, Xi Xi: Nutritional intake should be balanced, and one should avoid excessive consumption of a single component.
It is recommended to use according to the suggested dosage and not to exceed it.

Reply Date: 2023/07/27

More Info


Zinc is an essential trace mineral that plays a crucial role in various physiological functions, including immune response, protein synthesis, wound healing, DNA synthesis, and cell division. It is also known to influence appetite and taste perception. In patients with epilepsy, maintaining a balanced diet and proper nutritional intake is vital, as some antiepileptic medications can affect appetite and nutritional status.

Regarding your question about zinc supplementation for appetite issues in epilepsy patients, it is important to consider several factors. First, while zinc can help improve appetite, excessive intake can lead to toxicity and adverse effects. The recommended dietary allowance (RDA) for zinc varies by age and sex, but for adults, it is generally around 11 mg per day for men and 8 mg per day for women. Supplementation should not exceed the tolerable upper intake level (UL), which is 40 mg per day for adults, as higher doses can lead to nausea, vomiting, loss of appetite, stomach cramps, diarrhea, and headaches.

In the context of epilepsy, some studies suggest that zinc may have a neuroprotective effect and could potentially enhance the efficacy of certain antiepileptic drugs. However, there is also evidence indicating that high levels of zinc can interfere with the absorption of other essential minerals, such as copper and iron, which are also critical for overall health. Therefore, it is essential to maintain a balanced intake of all nutrients.

If you are considering zinc supplementation, it is advisable to consult with your healthcare provider, especially since you are already taking medication for appetite issues. Your doctor can evaluate your specific situation, including your current diet, medication regimen, and overall health status, to determine whether zinc supplementation is appropriate for you. They may also recommend a specific dosage if supplementation is deemed necessary.

Additionally, if you are experiencing significant appetite issues, it may be beneficial to explore other dietary strategies or interventions that can help improve your appetite. This could include eating smaller, more frequent meals, incorporating nutrient-dense foods, and possibly working with a nutritionist who can provide personalized dietary advice.

In summary, while zinc supplements may help with appetite issues in some individuals, including those with epilepsy, it is crucial to approach supplementation cautiously and under medical supervision. Balancing zinc intake with other essential nutrients and considering the potential interactions with your epilepsy medication is vital for maintaining optimal health and managing your condition effectively. Always prioritize open communication with your healthcare provider regarding any supplements or dietary changes you wish to make.

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