Managing Gastrointestinal Issues: Tips for Constipation Relief After PPI Use - Gastroenterology and Hepatology

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Gastrointestinal and bowel-related issues?


Hello doctor, I would like to ask about my condition.
I was diagnosed with grade C gastroesophageal reflux disease (GERD) and a gastric ulcer over a year ago after undergoing an endoscopy.
I have been taking a proton pump inhibitor (PPI), specifically Pantoprazole, for almost a year and a half.
My doctor mentioned that my GERD has improved to grade A, and my stomach condition is quite stable.
However, I am concerned about the side effects of long-term PPI use, as I often have difficulty with bowel movements.
I feel like I eat a lot but have little to no stool, and when I do, it is either watery or very little and poorly formed.
Currently, I am taking probiotics, laxatives, and eating dragon fruit to try to alleviate the issue, but I haven't seen any significant improvement.
Could you please advise me on any methods to improve this situation?

Mj, 20~29 year old female. Ask Date: 2023/07/27

Dr. Lin Minghui reply Gastroenterology and Hepatology


Due to severe gastroesophageal reflux disease (GERD) and gastric ulcers, the patient has been taking proton pump inhibitors (PPIs) for a year and a half.
The use of PPIs may lead to looser stools.
The patient often experiences constipation.
It is recommended that, in addition to being mindful of dietary habits related to gastroesophageal reflux, the patient should increase fiber and fluid intake, establish a regular exercise routine, and develop good bowel habits.
To alleviate constipation, it is important to drink plenty of water and consume fruits and vegetables.
In addition to dragon fruit, apples, papayas, kiwis, bananas, and pineapples are also rich in dietary fiber and can help promote intestinal motility.
Wishing you good health!

Reply Date: 2023/07/27

More Info


Managing gastrointestinal issues, particularly constipation after prolonged use of proton pump inhibitors (PPIs), can be a challenging experience. It’s great to hear that your gastroesophageal reflux disease (GERD) has improved, but the constipation you’re experiencing is a common concern among PPI users.
PPIs, such as the one you mentioned (逸潰定), are effective in reducing stomach acid production, which helps in healing ulcers and managing GERD symptoms. However, they can also lead to gastrointestinal side effects, including constipation. This is due to several factors, including changes in gut motility and alterations in the gut microbiome caused by reduced stomach acidity.
Here are some strategies to help alleviate constipation:
1. Dietary Adjustments: Increasing your fiber intake is crucial. Aim for a diet rich in fruits, vegetables, whole grains, and legumes. Foods like beans, lentils, and whole grains can help add bulk to your stool. Since you mentioned consuming dragon fruit, which is high in fiber, continue to incorporate it into your diet. Other high-fiber foods include apples, pears, berries, broccoli, and oats.

2. Hydration: Ensure you are drinking plenty of water throughout the day. Adequate hydration is essential for softening stool and promoting regular bowel movements. Aim for at least 8-10 glasses of water daily, and consider increasing this if you are consuming more fiber.

3. Physical Activity: Regular exercise can stimulate bowel function. Even simple activities like walking can help promote digestion and relieve constipation. Aim for at least 30 minutes of moderate exercise most days of the week.

4. Probiotics: While you are already taking probiotics, it may be beneficial to ensure you are using a high-quality product that contains a variety of strains. Probiotics can help restore the balance of gut bacteria, which may be disrupted by prolonged PPI use.

5. Over-the-Counter Remedies: If dietary changes and probiotics are not effective, you might consider using over-the-counter laxatives, but these should be used sparingly and not as a long-term solution. Laxatives like polyethylene glycol (MiraLAX) can be effective for occasional use. However, consult your healthcare provider before starting any new medication.

6. Routine: Establishing a regular bowel routine can also be beneficial. Try to set aside time each day to sit on the toilet, even if you don’t feel the urge. This can help train your body to have regular bowel movements.

7. Consult Your Doctor: Since you have been on PPIs for an extended period, it’s essential to discuss your constipation with your healthcare provider. They may want to evaluate your current medication regimen and consider alternatives or additional treatments to manage your symptoms effectively.

8. Monitor for Other Symptoms: Keep an eye on any other gastrointestinal symptoms you may experience, such as abdominal pain, bloating, or changes in stool consistency. If you notice any concerning changes, it’s important to seek medical advice.

In conclusion, while PPIs are effective for managing GERD and ulcers, they can lead to constipation as a side effect. By making dietary changes, staying hydrated, increasing physical activity, and possibly adjusting your probiotic intake, you can work towards alleviating your constipation. Always keep an open line of communication with your healthcare provider to ensure that your treatment plan is tailored to your needs and to address any ongoing concerns.

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