Distinguishing Between Immune Issues and Menopause Symptoms at 50 - Internal Medicine

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How to distinguish between immune issues and menopausal symptoms?


Hello, Doctor.
I am 50 years and 6 months old.
My menstrual cycle was regular until December of last year when it suddenly stopped.
Before March of this year, I experienced insomnia, excessive sweating, frequent colds and nasal congestion, itchy eyes, redness and dryness around the eyes, hip joint pain (pain when sitting down and getting up, with orthopedic X-rays showing only mild bone spurs), and soreness in my shoulders, neck, and back.
After April, in addition to more frequent insomnia and increased sweating, I continued to have mild soreness (which does not occur during physical activity when my body heats up and does not affect my ability to function), but no other symptoms.

In early July, my left hand's distal joints of the index and middle fingers suddenly swelled, turning red, swollen, painful, and difficult to bend.
After consulting with orthopedics and rehabilitation, I was finally diagnosed with Heberden's nodes by a rheumatologist.
I have been taking one Celebrex daily for three weeks, which has alleviated the pain, and now it feels like there are hard lumps when touched.
The immunology department conducted blood tests for over 40 items, and aside from urine total protein <4, white blood cell count 4.59, HLA-B27 positive, and Anti-nuclear antibody 40x+, everything else was normal (e.g., Anti-CCP 0.4, RF <10, C-reactive protein <0.1, ESR-1hr 4).

In the past six months, I have had no difficulty getting out of bed in the morning and can easily turn or move my limbs.
However, I experience tightness and stiffness in my back (previously from the lower back to the chest area, and recently from the chest to the shoulder area) that feels like my lower back cannot straighten or my neck is too heavy to lift my head.
This discomfort usually disappears by around 10 AM or at the latest by noon.
The doctor believes this is "morning stiffness," and along with my finger symptoms, prescribed "Saler."
Aside from the Heberden's nodes that occurred in July, I had previously experienced numbness in my upper arm due to cervical stenosis (which resolved after rehabilitation) in 2019.
My right knee occasionally feels stiff (this has been fluctuating for the past 10 years but has not reached a level requiring medical attention).
In terms of family history, my father and grandmother had recurrent redness and swelling in their toes and knees when they were younger, but there were no spinal symptoms, and they did not show significant kyphosis until around the age of 80.

I would like to ask the doctor: (1) What tests should be done to confirm whether there is inflammation or adhesion in the spine? (2) Is it possible for ankylosing spondylitis to develop at the age of 50? (3) I have been exercising regularly for 10 years, and some movements similar to gymnastics involve supporting my body with my hands.
I have a sedentary job where I sit in front of a computer all day under significant stress, and poor posture and cumulative injuries from exercise are inevitable.
Additionally, my insomnia prevents me from resting (I used to fall asleep easily, but now lying down for a while makes my body feel stiff and unable to relax).
Is it possible that I am only experiencing muscle fascia issues, menopausal disturbances, or autonomic nervous system disorders, rather than an immune problem? (4) Since early July, I have been taking one Celebrex daily, and aside from the alleviation of finger pain, my overall physical condition has not changed (I have only been on Saler for 10 days).
Given that my blood tests are considered normal, if it does not affect my daily life, can I stop taking Saler and Celebrex? I apologize for having so many questions.
My doctor answers when asked but does not provide explanations proactively, and I still cannot figure out what is happening with my body.
Thank you, Doctor!

Kate, 50~59 year old female. Ask Date: 2023/07/31

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your question.
Here are my responses:
(1) What tests should be done to confirm if there is inflammation or adhesion in the spine? --> X-rays and blood tests are sufficient.
If necessary, an MRI may also be arranged.
Your physician may have started treatment due to a positive HLA-B27 test combined with clinical symptoms.
(2) Is it possible for ankylosing spondylitis to develop by the age of 50? --> Yes, it is possible.
One reason could be regular exercise, which may delay the onset of symptoms that typically appear at a younger age.
(3) I have been exercising regularly for 10 years, and some movements similar to gymnastics involve supporting my body with my hands.
I also sit for long periods at work in front of a computer under significant stress, leading to poor posture and the accumulation of exercise-related injuries.
Additionally, I have insomnia and cannot rest well (previously I would fall asleep immediately, but now I feel stiff and unable to relax after lying down for a while).
Is it possible that I am only experiencing myofascial issues, menopausal symptoms, or autonomic nervous system disorders, rather than an immune problem? --> It is still possible.
Generally, ankylosing spondylitis responds well to anti-inflammatory pain relievers, so if you have not seen improvement after taking Celebrex, it is important to consider the possibility of other conditions.
(4) I have been taking one Celebrex daily since early July, and while the pain in my fingers has alleviated, my overall condition has not changed (I have been on Salazopyrin for 10 days).
Since my blood tests are normal, can I stop taking Salazopyrin and Celebrex if it does not affect my daily life? --> Salazopyrin takes some time to reach its maximum effect, generally around three months.
Therefore, during this period, anti-inflammatory pain relievers like Celebrex are very important.
If it does not affect your daily life, some patients with mild symptoms and normal blood tests may choose to maintain regular exercise and periodic blood tests to monitor their condition while coexisting with the disease.
Thus, you can discuss with your physician to choose the treatment approach that you feel most comfortable with.

Best regards from the Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare.

Reply Date: 2023/07/31

More Info


At 50 years old, experiencing a sudden cessation of menstruation along with a variety of symptoms can indeed raise questions about whether these issues are related to menopause or an underlying immune problem. Let's break down your concerns and symptoms to provide a clearer understanding.


1. Confirming Inflammation or Adhesions in the Spine: What Tests to Conduct?
To assess for inflammation or adhesions in the spine, imaging studies such as X-rays and potentially an MRI (Magnetic Resonance Imaging) are recommended. X-rays can reveal structural changes, while an MRI provides detailed images of soft tissues, including the spinal cord and surrounding structures. Given your symptoms of morning stiffness and discomfort in the back, these tests can help determine if there is any inflammatory condition present, such as ankylosing spondylitis.


2. Can Ankylosing Spondylitis Onset Occur at Age 50?
While ankylosing spondylitis (AS) typically presents in younger individuals, it is not impossible for symptoms to manifest later in life. The condition is characterized by inflammation of the spine and can sometimes be triggered or exacerbated by lifestyle factors, including prolonged poor posture or physical stress. Your history of regular exercise and the sudden onset of symptoms may suggest that the underlying condition was present but not symptomatic until now.


3. Could Symptoms Be Due to Muscle-Fascial Issues, Menopause, or Autonomic Nervous System Dysregulation?
Your symptoms, including persistent pain, stiffness, and sleep disturbances, could indeed be attributed to several factors. Menopause can lead to hormonal changes that affect mood, sleep, and overall physical health. Additionally, muscle-fascial pain syndromes can arise from prolonged sitting, poor posture, and stress, leading to tension and discomfort. The autonomic nervous system can also be affected by stress and hormonal changes, contributing to symptoms like insomnia and muscle tightness.
Given your family history of joint issues and the presence of Heberden's nodes, it is essential to consider autoimmune conditions. The positive HLA-B27 and elevated anti-nuclear antibodies (ANA) suggest a potential autoimmune component, but the absence of other inflammatory markers (like elevated CRP or ESR) may indicate that while there is an immune response, it may not be fully active at this time.


4. Can You Discontinue Medications If Symptoms Are Manageable?
Regarding your current medications, it is crucial to have a discussion with your healthcare provider. While you may feel that your symptoms are manageable, medications like Celebrex (希樂保) and Salazopyrin (撒樂) often require a consistent regimen to maintain their therapeutic effects. Stopping them abruptly could lead to a resurgence of symptoms. If your blood tests are stable and you are not experiencing significant issues, your doctor may suggest a tapering strategy or alternative management approaches, including lifestyle modifications, physical therapy, or regular monitoring.


Conclusion
In summary, your symptoms could stem from a combination of menopause, potential autoimmune issues, and lifestyle factors. It is essential to work closely with your healthcare provider to monitor your condition, conduct necessary tests, and adjust your treatment plan as needed. Open communication with your doctor about your concerns and symptoms will help clarify your diagnosis and guide you toward the most effective management strategies. Regular follow-ups and possibly a referral to a rheumatologist may also be beneficial in addressing your autoimmune concerns comprehensively.

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