Managing Heart Medication: Dosage Questions for Catapres in Arrhythmia - Cardiology

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What is the recommended dosage for the heart medication Kadycyn?


Hello, doctor.
I am currently 51 years old, 174 cm tall, and weigh 89 kg.
I experienced paroxysmal supraventricular tachycardia at the age of 29 and underwent successful catheter ablation at 33, but later discovered I still had atrial flutter and ventricular fibrillation.
Before the ablation, I was on Isoptin, and after the procedure, I was prescribed Cordarone 200 mg once daily.
After several years of using Cordarone, my pulse slowed to 40-50 beats per minute, and my heart rhythm became irregular, causing discomfort for years.
After discussions with my doctor, the medication was changed to 90 mg of Dronedarone (Kaitianshin), taking one tablet at 11 am and one at 11 pm.
My heart rhythm remains irregular, but the discomfort has lessened to a manageable state.
I maintained this regimen until I turned 51.
Initially, at a weight of 78 kg, I only took one 90 mg Dronedarone tablet, but after my weight increased to 94 kg, I switched to taking one tablet in the morning and one in the evening (this has been the case for about five years).
After turning 51, I bought a blood pressure monitor and have been measuring my blood pressure several times daily.
It typically reads 125/85, but in the evening, when I feel unwell, my blood pressure readings are 95/68 and 101/69, with a heart rate of about 80-92.
Every evening when I feel uncomfortable (which gives me a sensation of limited mobility), my blood pressure readings are consistently around 100/68.

Q1: Therefore, I wonder if I can reduce my Dronedarone dosage to just one 90 mg tablet.

Q1-1: Does Dronedarone maintain its therapeutic concentration for 24 hours?
Q2: Can Dronedarone be replaced with a lower dose, such as 160 mg of Dronedarone (Dronedarone) or even lower? I feel I am sensitive to medications, as I have been able to sleep with just 5 mg of Stilonx and 0.5 mg of Rifampicin for over 15 years without increasing the dosage of my sleeping medication.

Q2: If this is feasible, I would then consult my doctor.
I am also unsure why I am experiencing low blood pressure at this time.
In any case, this low blood pressure is making me feel very uncomfortable.

Mr. Su, 50~59 year old female. Ask Date: 2023/08/03

Dr. Chen Jili reply Cardiology


Recommendation: Please discuss the above situation further with your attending physician.
Thank you.
Wishing you good health!

Reply Date: 2023/08/03

More Info


Managing heart medication, especially in the context of arrhythmias, requires careful consideration of both the medications being used and the patient's overall health status. In your case, it seems you have a history of paroxysmal supraventricular tachycardia (SVT) and atrial flutter/fibrillation, which complicates your treatment regimen.

Understanding Your Current Medications
You mentioned that you have been on Cordarone (Amiodarone) and then transitioned to Catapres (Clonidine). Amiodarone is a potent antiarrhythmic medication that can help control heart rhythm but is known for its side effects, including bradycardia (slow heart rate) and potential thyroid dysfunction. The fact that you experienced a heart rate as low as 40-50 beats per minute while on Amiodarone suggests that the medication may have been too strong for your needs, especially if you were feeling uncomfortable.


Dosage Considerations
1. Reducing Catapres Dosage:
- You are currently taking two 90 mg doses of Catapres daily. Given your weight increase and the fact that you are experiencing low blood pressure readings (especially in the evening), it may be reasonable to discuss with your physician the possibility of reducing your Catapres dosage to one 90 mg tablet per day.
- Clonidine typically has a duration of action of about 8-12 hours, so taking it twice daily is common. However, if you find that your blood pressure is consistently low and you are feeling uncomfortable, this could indicate that your current dosage is too high for your needs.

2. Maintaining Medication Levels:
- Clonidine does not have a long half-life, so it is important to take it as prescribed to maintain stable blood levels. If you reduce the dosage, monitoring your blood pressure and heart rate closely will be essential to ensure that you do not experience rebound hypertension or other complications.

3. Switching to Diovan (Valsartan):
- You asked whether Diovan could replace Clonidine. Valsartan is an angiotensin receptor blocker (ARB) that is often used to manage hypertension and heart failure. It may not have the same effects on heart rhythm as Clonidine, which is primarily used for its central nervous system effects to lower blood pressure and manage certain types of arrhythmias.
- If you are sensitive to medications, as you indicated with your response to Stilonx and Rifampicin, it is crucial to approach any changes cautiously. Discussing this with your doctor is essential, as they can help determine if switching to Valsartan is appropriate for your specific situation.


Addressing Low Blood Pressure
Your reported evening blood pressure readings (around 95/68) suggest that you may be experiencing hypotension, which can lead to symptoms like dizziness, fatigue, and a general feeling of discomfort. This could be due to several factors, including:
- Medication Effects: Both Clonidine and Amiodarone can lower blood pressure. If you are experiencing low readings, it may be a direct effect of these medications.

- Fluid Status: Dehydration or inadequate fluid intake can also contribute to low blood pressure. Ensure you are drinking enough fluids throughout the day.

- Dietary Factors: High sodium intake can sometimes help raise blood pressure, but this should be approached cautiously, especially in patients with heart conditions.


Conclusion
Given your complex medical history and current symptoms, it is crucial to have an open dialogue with your healthcare provider about your medication regimen. Discuss the possibility of adjusting your Catapres dosage and the potential for switching to Diovan. Regular monitoring of your blood pressure and heart rate will be essential in managing your symptoms effectively. Always consult your physician before making any changes to your medication to ensure that it aligns with your overall treatment plan and health goals.

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