Impact of One Month NSAID Use on Kidney Health: What You Need to Know - Urology

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The impact of NSAID use on the kidneys after one month?


Hello Doctor, I recently visited a dermatologist due to skin issues.
The doctor prescribed tetracycline and also a non-steroidal anti-inflammatory drug: enteric-coated diclofenac (two tablets a day).
I was informed that it should not be used long-term, but there was no specific guidance on when to stop the medication.
After my follow-up visit, the prescription continued, resulting in my taking this anti-inflammatory medication for a month.
I have learned that this type of medication can significantly affect the kidneys, and I would like to know if my usage duration qualifies as "long-term use" and whether I should go to the hospital for a blood test to check my kidney function.
Thank you, Doctor.

Zhang, 10~19 year old female. Ask Date: 2023/08/13

Dr. Du Shixi reply Urology


Hello: In my personal opinion, a one-month period should not have a significant impact, unless there were pre-existing abnormalities in kidney function that would require regular monitoring.
Wishing you good health.

Reply Date: 2023/08/13

More Info


The use of non-steroidal anti-inflammatory drugs (NSAIDs) has been a common practice for managing pain and inflammation. However, prolonged use of these medications can have significant implications for kidney health. In your case, taking an NSAID for one month raises valid concerns, especially considering the potential impact on renal function.


Understanding NSAIDs and Kidney Health
NSAIDs, such as ibuprofen, naproxen, and others, work by inhibiting the production of prostaglandins, which are compounds involved in inflammation and pain signaling. While effective for short-term relief, these medications can lead to adverse effects, particularly on the kidneys, when used over extended periods. The kidneys rely on prostaglandins to maintain adequate blood flow and filtration. When NSAIDs inhibit these compounds, it can result in reduced renal perfusion, leading to acute kidney injury (AKI) or exacerbation of pre-existing kidney conditions.


Duration of Use
In general, the term "long-term use" can vary based on individual health conditions and the specific NSAID being used. A month of continuous NSAID use is often considered significant, especially if there are underlying risk factors such as pre-existing kidney disease, dehydration, or concurrent use of other nephrotoxic medications. If you have no prior kidney issues and are otherwise healthy, a month of NSAID use may not immediately lead to kidney damage, but it is essential to monitor your kidney function, especially if you experience symptoms like decreased urine output, swelling, or fatigue.


Recommendations for Monitoring Kidney Function
Given your concerns, it would be prudent to consult with your healthcare provider about the necessity of kidney function tests. Common tests include:
1. Serum Creatinine: This test measures the level of creatinine in your blood, which can indicate how well your kidneys are filtering waste.

2. Blood Urea Nitrogen (BUN): This test assesses the amount of nitrogen in your blood that comes from urea, a waste product formed in the liver.

3. Urinalysis: This test can help detect abnormalities in your urine that may indicate kidney issues.

If you have any risk factors for kidney disease or if you experience any concerning symptoms, it is advisable to have these tests done sooner rather than later.


Conclusion
In summary, while one month of NSAID use may not universally be classified as "long-term," it is essential to be vigilant about potential kidney impacts. Regular monitoring of kidney function through blood tests is recommended, especially if you have any underlying health conditions or if you notice any changes in your health status. Always consult with your healthcare provider for personalized advice and to determine the best course of action regarding your medication regimen and kidney health.

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