Gastrointestinal Bleeding from Anticoagulants: Key Insights - Cardiology

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Gastrointestinal bleeding caused by anticoagulants?


Hello Doctor: Recently, I have noticed that I have been experiencing black stools.
Initially, I thought it was due to eating chocolate, but after stopping for two days, the issue persisted.
Today, I realized it might be related to the medication Pusanda.
Additionally, I took Panadol for several days due to a recent cold, and I am concerned that this may have caused gastrointestinal bleeding.
I have also been feeling a dull, heavy sensation in my left flank.
I found information indicating that drug-induced gastric ulcers require a gastric mucosal protectant (such as Sucralfate), and after taking it at noon, the heaviness in my left flank has decreased, which further suggests that I might have a gastric ulcer.

However, I have the following questions:
1.
Should I continue taking Pusanda? Should I reduce the dosage from twice a day to once a day, or should I consult my cardiologist for advice?
2.
Is Sucralfate effective in treating drug-induced gastric ulcers? Since I have a follow-up appointment with the gastroenterologist on September 4th, should I inform the doctor about the need for an endoscopy and cauterization?
Thank you for your assistance with these questions!

josephy, 50~59 year old female. Ask Date: 2023/08/24

Dr. Huang Yinghe reply Cardiology


Hello: Please discontinue Prasugrel and return to the cardiology and gastroenterology departments as soon as possible.
Anticoagulants generally do not directly cause bleeding, but if there are lesions in the gastrointestinal mucosa, it may exacerbate bleeding.
Based on the symptoms, gastrointestinal bleeding is suspected, but further examination is necessary for confirmation.
Sometimes, if the issue is in the lower gastrointestinal tract (colon or small intestine), gastric mucosa protection may not be effective.
The physician will determine the most appropriate management based on your condition.

Reply Date: 2023/08/24

More Info


Gastrointestinal (GI) bleeding is a serious medical condition that can arise from various causes, including the use of anticoagulants like Prasugrel (普栓達) and other medications. Your concerns about the black stools, which may indicate upper GI bleeding, warrant careful consideration and prompt medical attention.


Understanding the Causes of GI Bleeding
1. Anticoagulants and Bleeding Risk: Anticoagulants, such as Prasugrel, are commonly prescribed to prevent blood clots, especially in patients with cardiovascular conditions. However, they can increase the risk of bleeding, including gastrointestinal bleeding. This is particularly true if the patient has underlying conditions such as peptic ulcers or gastritis, which can be exacerbated by these medications.

2. Other Medications: You mentioned taking Paracetamol (普拿疼) for a cold. While Paracetamol is generally considered safer for the stomach than non-steroidal anti-inflammatory drugs (NSAIDs), it can still contribute to liver stress, especially in high doses or with prolonged use. It's essential to evaluate all medications being taken, as some may interact and increase the risk of bleeding.

3. Symptoms and Diagnosis: The presence of black stools (melena) often indicates that there is bleeding in the upper GI tract, such as from a bleeding ulcer or gastritis. The "dull" sensation in your left flank could be related to referred pain from the gastrointestinal tract or could indicate another issue that needs to be evaluated.


Recommendations for Management
1. Consult Your Cardiologist: Given your history of anticoagulant use, it is crucial to consult your cardiologist before making any changes to your medication regimen. They can assess the risks and benefits of continuing Prasugrel, especially in light of your recent symptoms. It may be necessary to adjust the dosage or switch to a different medication that poses a lower risk for GI bleeding.

2. Medication for Gastric Protection: You mentioned starting a mucosal protective agent (生達保胃乳). While these medications can help protect the stomach lining and reduce the risk of ulcers, they may not be sufficient alone if there is an active ulcer or significant bleeding. It is essential to follow up with your gastroenterologist, especially if you have ongoing symptoms.

3. Endoscopy Consideration: If your symptoms persist or worsen, it may be necessary to undergo an endoscopy (胃鏡) to directly visualize the gastrointestinal tract and assess for ulcers or other sources of bleeding. Your gastroenterologist can determine the appropriate timing for this procedure based on your symptoms and medical history.

4. Monitoring and Follow-Up: Keep track of your symptoms, including any changes in bowel habits, abdominal pain, or new symptoms. Regular follow-up appointments with both your cardiologist and gastroenterologist are essential to manage your medications and monitor for any complications.


Conclusion
In summary, gastrointestinal bleeding can be a complex issue, especially when anticoagulants are involved. It is crucial to work closely with your healthcare providers to manage your medications, monitor your symptoms, and determine the need for further diagnostic procedures. Always communicate openly about any new symptoms or concerns, as this will help ensure that you receive the most appropriate care.

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