Side Effects of Restasis: Is Your Eye Discomfort Normal? - Ophthalmology

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Side effects of eye drops?


The Restasis Ophthalmic Emulsion (0.05%) package insert mentions side effects such as burning sensation in the eyes, conjunctival hyperemia, increased discharge, foreign body sensation, itching, stinging, and blurred vision.
I have a history of dry eye syndrome with corneal abrasions, and after applying the eye drops approved by health insurance, I experience a burning sensation and stinging throughout the day.
Is this normal? Should I discontinue the use of the eye drops? Thank you.

Xiao Zhu, 40~49 year old female. Ask Date: 2023/09/08

Dr. Gao Pilin reply Ophthalmology


Hello: 1.
Consult with your physician: First, I recommend that you consult your ophthalmologist immediately.
These side effects may be abnormal and could indicate an intolerance to the eye drops.
The ophthalmologist can assess your condition and determine whether a treatment adjustment or discontinuation of Restasis is necessary.
2.
Do not discontinue medication on your own: Please do not stop using the medication without guidance; instead, adjust your treatment under the supervision of your ophthalmologist.
Discontinuing the medication may affect your dry eye symptoms, and it is essential to have a physician's advice for proper management.
3.
Document symptoms: Before consulting with your physician, you can record the symptoms and discomfort experienced after using Restasis.
This will help the physician better understand your situation and make appropriate treatment recommendations.
4.
Explore alternative options: If you are intolerant to Restasis, the ophthalmologist may consider other treatment options, such as different eye drops or therapies, to ensure proper management of your dry eye condition.

Reply Date: 2023/09/08

More Info


When using Restasis (Cyclosporine A) ophthalmic emulsion, it is common to experience some side effects, especially if you have pre-existing conditions like dry eye syndrome. The side effects you mentioned—burning sensation, stinging, increased discharge, foreign body sensation, itching, and blurred vision—are indeed listed in the product information and can occur in some patients.

Firstly, it is important to understand that Restasis is designed to help increase tear production in patients with dry eye disease. The mechanism of action involves reducing inflammation in the eye, which can lead to an improvement in the symptoms of dry eyes over time. However, during the initial period of treatment, some patients may experience discomfort as their eyes adjust to the medication.

The burning and stinging sensations you are experiencing after instilling the drops are not uncommon. Many patients report these sensations, particularly when they first start using the medication. This discomfort is usually temporary and may lessen as your eyes adapt to the treatment. However, if the discomfort is severe or persists throughout the day, it is essential to consult your eye care provider.

In cases where the side effects are intolerable, your doctor may recommend adjusting the dosage or switching to a different treatment option. It is crucial not to stop using Restasis without consulting your healthcare provider, as discontinuing the medication could hinder the improvement of your dry eye symptoms.

Additionally, if you have a history of corneal abrasions or other ocular surface issues, it is vital to monitor your symptoms closely. If you notice any worsening of your condition, such as increased redness, pain, or changes in vision, you should seek medical attention promptly.

In summary, while some discomfort is expected with Restasis, it should not be overwhelming. If your symptoms are significantly impacting your quality of life, please reach out to your eye care professional for further evaluation and management. They may suggest alternative therapies, such as preservative-free artificial tears, punctal plugs, or other medications that may be better tolerated and more effective for your specific condition. Remember, managing dry eye syndrome often requires a multifaceted approach, and your healthcare provider can help tailor a treatment plan that best suits your needs.

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