the Transition from Hyperthyroidism to Hypothyroidism - Internal Medicine

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Hyperthyroidism to hypothyroidism?


Hello Doctor, in April I was diagnosed with hyperthyroidism with T4: 5.1 and TSH: <0.005.
After medication, my levels dropped to low in late May.
The doctor advised me to stop the medication for three to five days and then continue with a reduced dosage.
By July, both T4 and TSH returned to normal values.
However, I recently tested and found T3: 82.0 (normal), Free T4: 0.981 (normal), and TSH: 5.40 (slightly elevated).
Does this indicate a return to hypothyroidism? Is this considered serious? Currently, I am taking the following medications: 1.
"Yao Liang" heart rhythm tablet 10 mg (one tablet after breakfast and dinner daily) 2.
"Pan Sheng" propylthiouracil 50 mg (one tablet after each meal daily) 3.
Zanax 0.5 mg (one tablet before bed daily).
Since my next appointment is still nearly half a month away, can I reduce the dosage on my own? Additionally, I have experienced some hair loss; is it safe to take vitamins B, C, D, iron, and zinc? Thank you, Doctor.

Mau, 30~39 year old female. Ask Date: 2023/09/12

Dr. Li Jian reply Internal Medicine


Hello: It is recommended to visit the Department of Endocrinology and Metabolism at a major hospital for diagnosis and treatment.
Thank you for your inquiry.

Reply Date: 2023/09/12

More Info


Understanding the transition from hyperthyroidism to hypothyroidism is crucial for managing thyroid disorders effectively. In your case, it appears that you have experienced fluctuations in thyroid hormone levels, which is not uncommon in individuals undergoing treatment for hyperthyroidism.

Hyperthyroidism, characterized by elevated levels of thyroid hormones (like T4 and T3) and suppressed TSH (Thyroid Stimulating Hormone), can lead to symptoms such as weight loss, increased heart rate, anxiety, and heat intolerance. Treatment often involves antithyroid medications, radioactive iodine, or surgery, depending on the underlying cause and severity of the condition.

In your situation, after starting treatment, your T4 levels decreased, and TSH levels became suppressed, indicating a transition towards normal thyroid function. However, it is essential to monitor these levels closely, as the body can sometimes overcorrect, leading to hypothyroidism, where TSH levels rise and thyroid hormone levels drop. Your recent lab results show a TSH level of 5.40, which is indeed elevated, suggesting that your thyroid function may be leaning towards hypothyroidism.

The transition from hyperthyroidism to hypothyroidism can occur for several reasons, including:
1. Over-treatment: If the dosage of antithyroid medication is too high, it can suppress thyroid hormone production excessively, leading to hypothyroidism.

2. Autoimmune Response: Conditions like Hashimoto's thyroiditis can develop after treatment for hyperthyroidism, where the immune system attacks the thyroid gland, reducing hormone production.

3. Iodine Levels: Changes in dietary iodine intake or iodine supplementation can also influence thyroid function.

Regarding your current medications, it is essential to follow your physician's guidance on dosage adjustments. While it may be tempting to reduce your medication on your own, it is crucial to consult with your healthcare provider before making any changes. Abruptly altering your medication regimen can lead to significant fluctuations in thyroid hormone levels, which can have adverse effects on your health.

As for your concerns about hair loss, it is not uncommon for individuals with thyroid disorders to experience changes in hair health. Nutritional support, including vitamins B, C, D, iron, and zinc, can be beneficial for overall health and may support hair health. However, it is advisable to discuss any supplementation with your healthcare provider to ensure that it does not interfere with your thyroid medications or overall treatment plan.

In summary, your recent lab results indicate a potential shift towards hypothyroidism, which requires careful monitoring and possibly adjustments in your treatment plan. It is vital to maintain open communication with your healthcare provider, adhere to prescribed medications, and avoid self-adjusting dosages without professional guidance. Regular follow-ups and lab tests will help ensure that your thyroid levels remain stable and within the normal range, allowing you to manage your condition effectively.

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