Do Antibiotics Affect STD Test Accuracy? Key Insights for Patients - Urology

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Do general antibiotics affect the accuracy of sexually transmitted infection testing?


I previously took antibiotics such as Lidaoxin and Doxycycline for sinusitis, as well as antibiotics for urinary tract infection.
Will these affect the testing for gonorrhea or Chlamydia? How long should I stop the medications before retesting?

Xinxin, 30~39 year old female. Ask Date: 2023/09/15

Dr. Du Shixi reply Urology


Hello: Since antibiotics can also be effective in treatment, if the infection is cured, there is a possibility that it may not be detectable.
Generally, for conditions like gonorrhea, chlamydia, or urinary tract infections, one should seek medical attention if symptoms are present.
If asymptomatic, it is advisable to get tested within 7-14 days.
Personally, I do not recommend discontinuing medication.
Wishing you good health.

Reply Date: 2023/09/15

More Info


Antibiotics can indeed have an impact on the accuracy of sexually transmitted disease (STD) tests, particularly for infections such as gonorrhea and chlamydia. When a patient is treated with antibiotics, the medication can effectively eliminate the bacteria responsible for these infections, which may lead to a negative test result even if the infection was present prior to treatment. This is particularly relevant for tests that rely on the presence of the bacteria in the sample being tested.

For instance, if you have been taking antibiotics like Lidaoxin (立達信) for sinusitis or other infections, and you are concerned about the accuracy of STD tests for gonorrhea or chlamydia, it is essential to consider the timing of your testing in relation to your antibiotic treatment. The antibiotics may clear the infection, resulting in a false negative if you test too soon after completing your course of treatment.
In general, it is recommended to wait at least 7 to 14 days after completing antibiotic treatment before undergoing STD testing. This waiting period allows enough time for the antibiotics to clear from your system and for any remaining bacteria to multiply to detectable levels if the infection is still present. Testing too soon after antibiotic treatment may not provide an accurate reflection of your current health status.

Moreover, it is important to note that while antibiotics can treat bacterial infections, they do not affect viral infections such as HIV or herpes. Therefore, if you are being tested for viral STDs, the use of antibiotics will not impact the results.

In your case, since you have taken antibiotics for sinusitis and urethritis, it would be prudent to consult with your healthcare provider regarding the appropriate timing for your STD tests. They may recommend a follow-up appointment to discuss your symptoms and any potential need for retesting based on your treatment history.

Additionally, if you are experiencing symptoms of an STD, such as unusual discharge, pain during urination, or pelvic pain, it is crucial to seek medical attention regardless of your antibiotic use. Symptoms can indicate an active infection that may require further evaluation and treatment.

In summary, while antibiotics can affect the accuracy of STD tests by potentially leading to false negatives, waiting a sufficient period after completing treatment before testing can help ensure more reliable results. Always communicate openly with your healthcare provider about any medications you are taking and any symptoms you are experiencing to receive the best possible care.

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