Genital Herpes: Diagnosis, Misdiagnosis, and Family Planning - Urology

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Genital herpes


Hello, I recently noticed red spots on the inner side of my foreskin after retracting it, specifically in the area of the non-retracted folds.
The red spots are itchy, and they hurt when exposed to water during bathing.
The next day, I visited a urologist and found that one of the red spots had a blister.
The doctor diagnosed it as genital herpes and prescribed antibiotics and antiviral medication.
However, after learning that genital herpes is a lifelong condition, I returned for a follow-up three days later and had a herpes 1+2 IgG test done, which came back negative: Type 1 at 0.03 (<0.6) and Type 2 at 0.08 (<0.51).
The doctor mentioned that if it is a primary infection, it is very likely that the antibodies have not yet developed.
I would like to ask: 1.
If I have already had an outbreak, can I feel reassured with a negative result of 0.08? 2.
Is there a high chance of misdiagnosis for genital herpes? I only saw one blister, and the others were just red spots; I also did not experience the pus and crusting mentioned online (I did not feel any rough skin).
3.
If I am indeed unfortunate enough to have it, is there a way to ensure that I do not infect my partner while having children? Thank you, doctor.

Jidu buan de nanzi, 30~39 year old female. Ask Date: 2023/09/27

Dr. Li Xinyi reply Urology


The general IgG antibody test typically detects antibodies after an approximate window period of three months.
If there is a concern, it is advisable to retest three months later.
The symptoms of genital herpes can vary significantly; the purulent discharge and crusting you mentioned are generally more severe symptoms associated with the initial infection.
If a pregnant woman has a history of herpes infection, it is particularly important to monitor her condition during the last three months of pregnancy and discuss it with her obstetrician.

Reply Date: 2023/09/27

More Info


Genital herpes is a common sexually transmitted infection caused by the herpes simplex virus (HSV), primarily HSV type 1 and type 2. Understanding the diagnosis, potential for misdiagnosis, and implications for family planning is crucial for individuals experiencing symptoms or who have been diagnosed with this condition.

1. Understanding Your Diagnosis: You mentioned that you were diagnosed with genital herpes after noticing red spots and blisters. The diagnosis of genital herpes is typically based on the appearance of lesions and symptoms. However, laboratory tests, such as IgG antibody tests, are also used to confirm the diagnosis. In your case, the IgG results for both HSV-1 and HSV-2 were negative, which suggests that you may not have a past infection. However, it is important to note that if this is your first outbreak, it can take time for antibodies to develop, and they may not be detectable immediately. The presence of symptoms, such as itching and pain, can indicate an active infection, but the negative IgG results may suggest that this is not a recurrent infection.

2. Misdiagnosis Considerations: Misdiagnosis of genital herpes can occur, especially if the lesions are atypical or if there are other dermatological conditions that present similarly, such as contact dermatitis, folliculitis, or even other sexually transmitted infections. The fact that you only observed one blister and some red spots without the typical signs of herpes (such as multiple blisters, crusting, or significant discharge) raises the possibility of misdiagnosis. It is advisable to seek a second opinion or further testing if you have concerns about the accuracy of the diagnosis.

3. Family Planning and Prevention: If you are diagnosed with genital herpes, it is possible to have children while minimizing the risk of transmission to your partner. Here are some strategies:
- Communication: Inform your partner about your diagnosis and discuss ways to reduce the risk of transmission.

- Antiviral Medication: Taking antiviral medications during pregnancy can help reduce the risk of transmitting the virus to your baby during delivery.

- Safe Practices: Avoid sexual contact during outbreaks and consider using condoms to reduce the risk of transmission.

- Consultation with Healthcare Providers: It is essential to work closely with your healthcare provider, especially during pregnancy, to monitor your health and the health of your baby.

In conclusion, while a diagnosis of genital herpes can be concerning, understanding the nuances of testing and the potential for misdiagnosis can provide some reassurance. If you have further concerns about your diagnosis or implications for family planning, consider seeking a consultation with a specialist in infectious diseases or a reproductive health expert. They can provide personalized advice and support based on your specific situation.

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