Atrial Premature Contractions and Myocardial Ischemia Risks - Cardiology

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Cardiac issues


Hello: Since December of last year, I have been experiencing arrhythmia and shortness of breath.
A 24-hour Holter monitor showed over 13,000 premature atrial contractions.
I took Sotalol and Concor, but my discomfort did not improve.
Later, I switched to Sotalol and Dronedarone, which helped, but I am allergic to Dronedarone.
In September, a regional hospital referred me to a medical center, where the doctor indicated that the exercise stress test report showed myocardial ischemia.
However, I forgot to ask about the severity of the ischemia.
I am currently taking Metoprolol, Perindopril, Atorvastatin, and Aspirin.
The exercise stress test report is as follows; please assist in interpreting it.
Thank you.
Conclusion: Borderline (suspected positive) Duke Treadmill Score: +2 (Low risk: +5; Intermediate risk: +4 to -10; High risk: < -10)
Pre-exercise condition NYHA Class: Class II
Chest pain: Typical angina CCS Class: Class II
Resting ECG: Normal
Vital Signs:
Resting: 136/94 (HR: 81)
Exercise Stage 1: 165/102 (HR: 112)
Exercise Stage 2: 185/81 (HR: 132)
Exercise Stage 3: 171/71 (HR: 153)
Recovery 0 min: 175/70 (HR: 144)
Recovery 1 min: 170/74 (HR: 117)
Recovery 3 min: 152/82 (HR: 107)
Recovery 5 min: 151/92 (HR: 100)
Reason for termination: Dyspnea, Target HR, significant shortness of breath preventing continuation
Exercise time: 07 min 40 sec
Maximal HR: 86% (153/178)
ST changes:
Lead II: -1.0 (Upslope)
Lead III: -1.0 (Horizontal)
Lead aVF: -1.0 (Upslope)
Arrhythmia: None
Event: BP drop (-); Chest pain (-)
Note: Uneven baseline

Amanda, 40~49 year old female. Ask Date: 2023/09/28

Dr. Wu Xueming reply Cardiology


The exercise electrocardiogram shows signs suggestive of hypoxia.
Since it cannot be confirmed with absolute certainty, it is recommended to consult a cardiologist to discuss the possibility of further tests, such as a nuclear medicine myocardial perfusion scan.

Reply Date: 2023/09/28

More Info


Atrial Premature Contractions (APCs) and myocardial ischemia are two important cardiovascular concerns that can significantly impact a patient's health. Understanding their relationship and the associated risks is crucial for effective management and treatment.


Atrial Premature Contractions (APCs)
APCs are early heartbeats originating in the atria, which can disrupt the normal rhythm of the heart. They are common and often benign, especially in healthy individuals. However, in patients with underlying heart conditions, such as coronary artery disease (CAD) or myocardial ischemia, the presence of APCs can indicate an increased risk of more serious arrhythmias or cardiac events.
In your case, the report indicates that you have experienced a significant number of APCs (over 13,000 in 24 hours). This frequency can be concerning, particularly if accompanied by symptoms such as dyspnea (shortness of breath) or chest pain. The medications you are currently taking, including rhythm control agents like Sotalol (心利正) and other cardiovascular drugs, aim to manage these arrhythmias and reduce the risk of complications.


Myocardial Ischemia
Myocardial ischemia occurs when blood flow to the heart muscle is reduced, leading to a lack of oxygen. This condition can manifest as chest pain (angina) and can be triggered by physical exertion or stress. The exercise stress test you underwent provided valuable insights into your heart's response to exertion.
The Duke Treadmill Score of +2 indicates a borderline risk for ischemic heart disease. This score suggests that while you are not at high risk, there are still concerns that warrant close monitoring. The NYHA Class II classification indicates that you experience slight limitations in physical activity, which aligns with your reported symptoms of dyspnea during exercise.


Interpretation of Your Exercise Stress Test
1. Vital Signs and Heart Rate Response: Your heart rate increased appropriately during exercise, reaching 86% of the predicted maximum. However, the significant drop in blood pressure during recovery and the presence of dyspnea suggest that your heart may not be coping well under stress, which could be indicative of ischemia.

2. ST Segment Changes: The ST segment changes noted during the test (downsloping in leads II, III, and aVF) can be indicative of myocardial ischemia. These changes, particularly if they are significant, suggest that the heart muscle is not receiving adequate blood flow during exertion.

3. Chest Pain and Recovery: The absence of chest pain during the test is a positive sign, but the dyspnea experienced could be a sign of underlying ischemia or heart failure. The fact that you had to terminate the test due to shortness of breath is concerning and should be discussed with your cardiologist.


Recommendations
Given your history of APCs and the findings from your exercise stress test, it is essential to continue monitoring your heart health closely. Here are some recommendations:
1. Regular Follow-ups: Maintain regular appointments with your cardiologist to monitor your condition and adjust medications as necessary. Discuss any new symptoms or concerns you may have.

2. Medication Management: Continue taking your prescribed medications, including rhythm control and antiplatelet agents, as they play a crucial role in managing your heart condition. If you experience side effects from any medication, such as Dronedarone (臟得樂), inform your doctor immediately.

3. Lifestyle Modifications: Implement lifestyle changes that can improve your cardiovascular health. This includes a heart-healthy diet, regular physical activity (as tolerated), smoking cessation, and stress management techniques.

4. Further Testing: If symptoms persist or worsen, further diagnostic tests, such as coronary angiography, may be warranted to assess the severity of any coronary artery blockages.

5. Emergency Plan: Be aware of the signs of worsening ischemia or arrhythmias, such as severe chest pain, prolonged dyspnea, or syncope, and know when to seek immediate medical attention.

In conclusion, while APCs can be benign, their presence in the context of myocardial ischemia necessitates careful monitoring and management. Your current treatment plan and lifestyle adjustments will be pivotal in reducing your risk of future cardiac events. Always feel empowered to discuss your concerns with your healthcare provider to ensure you receive the best possible care.

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