Long-Term Use of Duasma: Risks of Glaucoma and Eye Pressure - Pulmonology

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Duasma (Dushuman) Issues


Hello doctor, due to my asthma, the doctor prescribed Duasma for me.
He mentioned that long-term use would not have significant issues because the dosage is low.
However, the medication's information does mention side effects such as glaucoma or increased intraocular pressure.
Can you tell me if long-term use of this medication could lead to glaucoma or elevated eye pressure?

Liu Xiansheng, 30~39 year old female. Ask Date: 2023/10/06

Dr. Huang Yiwen reply Pulmonology


Dear Mr.
Liu: It is true that the main ingredient of Duasma is a steroid, but because it is inhaled, the amount is indeed very small.
The warning is merely a reminder; the actual likelihood of occurrence is minimal and only relevant if there are specific issues.
You may refer to Changhua Hospital for further assistance.

Reply Date: 2023/10/06

More Info


Duasma, known generically as budesonide/formoterol, is an inhaled medication commonly prescribed for asthma and chronic obstructive pulmonary disease (COPD). It combines a corticosteroid (budesonide) with a long-acting beta-agonist (formoterol) to help reduce inflammation and relax the airways. While your doctor has assured you that long-term use of Duasma is generally safe and that the dosage is low, it is understandable to have concerns regarding potential side effects, particularly those related to eye health, such as glaucoma and increased intraocular pressure.

Corticosteroids, including budesonide, are known to have a potential side effect of increasing intraocular pressure, which can lead to glaucoma, especially when used in high doses or over extended periods. However, the risk associated with inhaled corticosteroids is significantly lower compared to systemic corticosteroids (those taken orally or injected). This is primarily due to the lower systemic absorption of inhaled medications, which means that less of the drug enters the bloodstream and reaches other parts of the body, including the eyes.

The warning about glaucoma and increased eye pressure in the medication's information is a precautionary measure. It serves to inform patients and healthcare providers of the potential risks, particularly for those who may already have risk factors for glaucoma, such as a family history of the disease, existing eye conditions, or other health issues. In your case, if you do not have any pre-existing conditions that predispose you to glaucoma, the likelihood of developing these issues from long-term use of Duasma is relatively low.

It is also important to consider that the dosage of the medication plays a crucial role in the risk of side effects. Since your doctor has prescribed a low dose, this further minimizes the risk. Regular monitoring of your eye health, especially if you have concerns or if you notice any changes in your vision, is advisable. If you experience symptoms such as blurred vision, seeing halos around lights, or persistent eye discomfort, you should consult with your healthcare provider promptly.

In summary, while there is a theoretical risk of increased intraocular pressure and glaucoma with long-term use of inhaled corticosteroids like Duasma, the actual risk is quite low, particularly at low doses. It is essential to maintain open communication with your healthcare provider about any concerns you may have and to undergo regular eye examinations, especially if you are using the medication for an extended period. Your doctor can help monitor your eye health and make any necessary adjustments to your treatment plan if needed.

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