Groin Pain and Iron Deficiency: Insights on Restless Legs - Neurology

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Groin discomfort, iron deficiency, restless legs syndrome, and tightness of the cremaster muscle?


Hello, doctor.
About 4-5 years ago, I underwent laparoscopic surgery for bilateral varicocele.
Approximately 1-2 years post-surgery, I started experiencing a dull pain in the right groin area.
I sought consultation with a urologist, and all examination results came back normal.
This year, the pain has expanded to the inner thigh, posterior side of the lower leg, and the right testicle, which sometimes experiences spasms and involuntary twitching, especially during thigh stretching exercises, which exacerbates the twitching.
I visited a neurologist for evaluation, and X-rays of the spine were normal, as were the nerve conduction studies.
The doctor initially prescribed Lyrica (pregabalin) and Levofloxacin, which provided significant relief.
Further blood tests revealed iron deficiency, and the doctor suspects it may be restless leg syndrome, so iron supplements were prescribed.
Recently, I've noticed that after sexual intercourse and ejaculation, the dull pain in the groin becomes more pronounced, and the cremaster muscle also feels tighter and spasms.
I searched online for restless leg syndrome but couldn't find any information regarding these symptoms.
Thank you for your assistance, doctor.

Mr. Chen, 20~29 year old female. Ask Date: 2023/10/07

Dr. Jiang Junyi reply Neurology


Hello Mr.
Chen,
You mentioned that "the pain has spread to the inner side of the right thigh, the outer side of the right calf, and the right testicle experiences spasms and sometimes involuntary twitching." These symptoms may suggest a neuropathy related to the sacral plexus.

Symptoms of peripheral neuropathy include:
1.
Pain characterized by burning or tingling sensations.
2.
Symptoms that follow a specific dermatomal distribution, which can be triggered by touch or pressure.
3.
Accompanied by muscle weakness and fatigue.
You mentioned medications such as Lyrica (pregabalin) and other similar drugs, which can generally alleviate symptoms of nerve instability.

Diagnosis of peripheral nerve issues typically involves electrophysiological studies.

- Nerve conduction studies assess the conduction velocity and waveform of large fiber nerves.
- Electromyography (EMG) evaluates muscle responses in the affected nerve distribution areas.
I recommend that you visit a neurology clinic for further evaluation and follow-up.
It would be beneficial to consult with a physician who specializes in peripheral nerves, as they have more experience with EMG testing.
Thank you for your inquiry.
If you have any further questions, feel free to discuss them!
Wishing you good health and peace,
Dr.
Jiang Junyi, Department of Neurology, Taoyuan Hospital

Reply Date: 2023/10/07

More Info


Understanding groin pain, especially in the context of previous surgeries and potential iron deficiency, can be complex. Your history of undergoing laparoscopic surgery for varicocele and the subsequent development of groin pain raises several considerations.
Firstly, the pain you describe in the right groin area, which has expanded to the inner thigh, back of the thigh, and outer calf, could be multifactorial. Given that you have already consulted urology and neurology, and both have ruled out significant structural or neurological issues, it is essential to consider other potential causes.
One possibility is that the pain may be related to musculoskeletal issues, such as muscle strain or tension in the pelvic region. The groin area is rich in muscles, tendons, and ligaments, and any strain or overuse can lead to discomfort. The fact that stretching the front thigh exacerbates the pain suggests that there may be tightness or irritation in the surrounding musculature.
Additionally, your report of experiencing spasms in the right testicle and the sensation of involuntary twitching could indicate a neuromuscular component. This could be related to the nerves that innervate the groin and thigh regions, which may have been affected during your previous surgery or could be a result of muscle tension and spasms.

The mention of iron deficiency is also significant. Iron deficiency can lead to a condition known as Restless Legs Syndrome (RLS), which is characterized by uncomfortable sensations in the legs and an uncontrollable urge to move them, often worsening at night or during periods of inactivity. While RLS typically does not cause groin pain directly, the discomfort and muscle cramps associated with it can contribute to a broader pain experience. The fact that your symptoms have improved with iron supplementation suggests that addressing the deficiency may help alleviate some of your discomfort.

The increase in groin pain following sexual activity and ejaculation could be related to pelvic floor muscle tension. The pelvic floor muscles play a crucial role in sexual function, and any tension or spasms in these muscles can lead to discomfort during or after sexual activity. This could explain why you experience increased tightness and pain in the groin area post-ejaculation.

In summary, your symptoms may be a combination of musculoskeletal pain, potential neuromuscular issues, and the effects of iron deficiency. Here are some recommendations:
1. Physical Therapy: Engaging in physical therapy focused on the pelvic region may help alleviate muscle tension and improve flexibility, potentially reducing pain.

2. Iron Supplementation: Continue with the iron supplements as prescribed by your physician, and monitor your iron levels to ensure they return to normal.

3. Pain Management: Discuss with your doctor the possibility of adjusting your pain management regimen if necessary, as medications like pregabalin (Lyrica) can help with nerve-related pain.

4. Follow-Up: Regular follow-ups with your healthcare providers are essential to monitor your symptoms and adjust treatment plans as needed.

5. Lifestyle Modifications: Incorporate gentle stretching and strengthening exercises for the pelvic and thigh muscles, and consider relaxation techniques to manage muscle tension.

If your symptoms persist or worsen, further evaluation may be warranted to rule out any underlying conditions that may not have been previously identified. Always consult with your healthcare provider before making any changes to your treatment plan.

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