Can You Take Lutein After PPI Medication? A Guide for Patients - Gastroenterology and Hepatology

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Issues with PPI medications?


Hello, doctor.
After undergoing an endoscopy, the physician indicated that there is mild inflammation and redness in my stomach and prescribed Dexilant (a PPI).
I would like to ask if it is acceptable to take the PPI before breakfast and then take lutein after a meal, or should there be a longer interval between the two medications?

Ting, 20~29 year old female. Ask Date: 2023/10/19

Dr. Hu Guozheng reply Gastroenterology and Hepatology


Drug metabolism takes time, and some medications may still interact even when taken separately.
It is advisable to consult your prescribing physician.
Thank you.

Reply Date: 2023/10/19

More Info


When it comes to taking medications, timing and interactions can be crucial for maximizing their effectiveness and minimizing potential side effects. In your case, you are asking about the timing of taking lutein after taking a proton pump inhibitor (PPI) like Dexilant (dexlansoprazole), which is prescribed for gastric inflammation and other acid-related conditions.

PPIs are typically taken before meals, usually in the morning, because they work best when there is no food in the stomach. They inhibit the proton pumps in the stomach lining, which reduces the production of stomach acid. This can be particularly beneficial for conditions like gastritis or peptic ulcers, as it allows the stomach lining to heal without the irritation caused by acid.

On the other hand, lutein is a carotenoid found in green leafy vegetables and is often taken as a dietary supplement for its potential benefits in eye health, particularly in reducing the risk of age-related macular degeneration. There is no specific requirement for lutein to be taken with or without food, but many people choose to take it with meals to enhance absorption, as it is fat-soluble.

Given this information, it is generally safe to take lutein after your PPI medication, as long as you follow the recommended timing for each. Here’s a suggested approach:
1. Take your PPI: Since PPIs are usually taken in the morning before meals, you should take your Dexilant as prescribed, ideally 30 minutes to an hour before breakfast.

2. Wait a little: After taking your PPI, it is advisable to wait at least 30 minutes before consuming any food. This allows the medication to start working effectively in reducing stomach acid.

3. Take lutein with food: After you have waited the appropriate time, you can then have your breakfast and take your lutein with your meal. This not only helps with the absorption of lutein but also ensures that your stomach is not overly acidic, which could potentially affect the absorption of other nutrients.

4. Consult your physician: While the above guidelines are generally safe, it is always best to consult your healthcare provider for personalized advice. They can provide specific recommendations based on your overall health, the medications you are taking, and any other conditions you may have.

In summary, you can take lutein after your PPI medication, ideally with food to enhance absorption. Just ensure you follow the timing guidelines for both medications. If you have any concerns about interactions or side effects, do not hesitate to reach out to your healthcare provider for further clarification. They can help you navigate your treatment plan effectively, ensuring that both your gastric health and nutritional needs are met.

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