Occult Blood in Urine: Implications for Kidney Health - Internal Medicine

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Occult blood?


Hello, Doctor Wu.
I would like to ask if there is a relationship between occult blood and the kidneys.
My occult blood level increased from 4+ to 5+.
Will this affect my kidneys? What does an occult blood level of 4+ indicate? My urine protein and other indices are normal, but my glomerular filtration rate (GFR) is 64, while the normal range is less than 60.
Is a GFR of 64 considered too low (it was 82 two years ago)? I also have high blood pressure.
Thank you for your response.
Sincerely, a worried patient.

Xiao Hua, 40~49 year old female. Ask Date: 2023/11/03

Dr. Wu Hongjie reply Internal Medicine


Hematuria and occult blood are different.
It is important to first confirm the presence of red blood cells in the urine.
If red blood cells are present, renal issues such as renal cysts, kidney lesions, stones, or tumors may need to be ruled out.
If there is only occult blood without red blood cells, in addition to the aforementioned causes, urinary tract infections and rhabdomyolysis should also be considered.
Rapid deterioration of renal function may occur, so follow-up with a nephrologist is advisable.
Wishing you health and safety.

Reply Date: 2023/11/03

More Info


Occult blood in urine, or hematuria, can be a significant indicator of underlying kidney or urinary tract issues. When you mention that your urine tests show occult blood levels of 4+ to 5+, it suggests a substantial presence of red blood cells in your urine, which is not normal. This condition can arise from various causes, including infections, stones, trauma, or more serious conditions like tumors or glomerular diseases.

The presence of occult blood, especially at levels of 4+ or higher, indicates a more severe situation that warrants further investigation. It is essential to understand that while the presence of blood in urine can be alarming, it does not always correlate directly with kidney function. However, it can be a sign of kidney distress or damage, especially if accompanied by other symptoms or abnormal lab results.

In your case, you mentioned that your glomerular filtration rate (GFR) is at 64, which is slightly above the threshold of 60 that is often used to define chronic kidney disease (CKD). While a GFR of 64 is not critically low, it does indicate that your kidney function is not optimal, especially compared to your previous reading of 82 two years ago. This decline could be due to various factors, including hypertension, which you mentioned you have. High blood pressure can lead to kidney damage over time, and it is crucial to manage it effectively to prevent further deterioration of kidney function.

The relationship between occult blood in urine and kidney health is complex. While the presence of blood can indicate issues within the kidneys or urinary tract, it does not automatically mean that your kidneys are failing. However, it does suggest that there may be an underlying issue that needs to be addressed. The fact that your urine protein levels are normal is a positive sign, as significant proteinuria can indicate more severe kidney damage.

Given your concerns, it is advisable to follow up with a nephrologist (kidney specialist) for a comprehensive evaluation. They may recommend additional tests, such as imaging studies (like an ultrasound or CT scan) or a kidney biopsy, depending on your specific situation. These tests can help determine the cause of the hematuria and assess the overall health of your kidneys.

In the meantime, managing your blood pressure is crucial. Lifestyle changes, including a balanced diet low in sodium, regular exercise, and maintaining a healthy weight, can significantly impact your kidney health. Additionally, staying well-hydrated is essential, as adequate fluid intake can help dilute the urine and may reduce the concentration of any irritants that could be causing hematuria.

In summary, while the presence of occult blood in urine and a GFR of 64 may raise concerns about kidney health, they do not necessarily indicate imminent kidney failure. However, they do warrant further investigation and management, particularly concerning your hypertension. Regular monitoring and proactive management of your kidney health are essential to prevent further complications. Please consult your healthcare provider for personalized advice and treatment options.

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