Blood Test Results: Insights on Liver Health and More - Gastroenterology and Hepatology

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Blood test value inquiry?


Hello, doctor.
Recently, my family arranged for a blood test at a laboratory, and I have some questions regarding the results.
Here are the liver-related values: Total Bilirubin: 1.1, Direct Bilirubin: 0.35, Total Protein: 7.4, Albumin: 5.0, Globulin: 2.4, Protein Ratio: 2.1, GOT (AST): 18, GPT (ALT): 17, ALK-P: 69, R-GT: 15, AFP: 1.68.
Most of these liver-related values are within the normal range, but the direct bilirubin is slightly elevated (normal value is 0.3).

1.
Are there any concerns regarding liver health based on these results?
2.
The laboratory staff mentioned that the levels of GOT and GPT are low and that this is also a concern.
Is this correct?
3.
Is it necessary to undergo an abdominal ultrasound based on these results?
4.
Recently, I have noticed that the whites of my eyes seem a bit yellow.
Could this be related to bloodshot eyes?
Additionally, I would like to inquire about the white blood cell count: 4222, Neutrophils: 41.7, Lymphocytes: 42.7, Monocytes: 8.5, Eosinophils: 5.9, Basophils: 1.2.
It seems that many of these values are slightly above the normal range.
What should I be aware of? The laboratory staff suggested that this could be an allergic reaction.

Niming, 40~49 year old female. Ask Date: 2023/11/12

Dr. Chen Shidian reply Gastroenterology and Hepatology


It is still within an acceptable range; a re-evaluation of the slightly abnormal parts can be done in 3 to 6 months for comparison.

Reply Date: 2023/11/12

More Info


When interpreting blood test results, especially those related to liver health and overall well-being, it is essential to understand the significance of each parameter and how they relate to potential health issues. Based on the values you provided, let's break down the results and address your concerns.


Liver Function Tests
1. Total Bilirubin (1.1 mg/dL) and Direct Bilirubin (0.35 mg/dL):
- Total bilirubin is a breakdown product of hemoglobin from red blood cells. Normal levels are typically below 1.2 mg/dL. Your total bilirubin is within the normal range, but the direct bilirubin is slightly elevated compared to the normal value of 0.3 mg/dL. Elevated direct bilirubin can indicate liver dysfunction, bile duct obstruction, or hemolysis (breakdown of red blood cells). It is important to monitor this value, especially if you notice any yellowing of the skin or eyes (jaundice).

2. Total Protein (7.4 g/dL), Albumin (5.0 g/dL), and Globulin (2.4 g/dL):
- These values are within normal ranges. Albumin is crucial for maintaining oncotic pressure and transporting substances in the blood. A normal albumin level suggests good liver function, as the liver produces albumin. The protein ratio (albumin to globulin) of 2.1 is also normal, indicating a balanced protein synthesis.

3. GOT (AST) and GPT (ALT):
- Both GOT (18) and GPT (17) are liver enzymes that help assess liver health. Normal values for these enzymes vary slightly by laboratory but are generally considered normal when below 40 U/L. Your values are low but still within the normal range. While low levels are not typically a cause for concern, they can indicate a lack of liver stress or damage. However, some clinicians may interpret low enzyme levels as a sign of malnutrition or liver dysfunction in certain contexts, so it’s worth discussing with your healthcare provider.

4. Alkaline Phosphatase (ALK-P) and Gamma-Glutamyl Transferase (GGT):
- Your ALK-P (69) and GGT (15) are also within normal limits. These enzymes are often elevated in cases of bile duct obstruction or liver disease. Normal levels suggest that there is no significant cholestasis (bile flow obstruction).

5. Alpha-Fetoprotein (AFP):
- An AFP level of 1.68 ng/mL is within the normal range. AFP is often used as a tumor marker for liver cancer, so normal levels are reassuring.


Additional Concerns
1. Jaundice:
- You mentioned noticing a yellow tint in your eyes. This could be a sign of elevated bilirubin levels, even if they are only slightly elevated. It’s essential to monitor this symptom closely and consult with a healthcare provider if it persists or worsens.

2. White Blood Cell Count:
- Your white blood cell count (4222) is slightly below the normal range (typically 4500-11000 cells/mcL). The differential count shows a predominance of lymphocytes (42.7%) and a lower percentage of neutrophils (41.7%). This could indicate a viral infection or an allergic reaction, as you mentioned. If you are experiencing symptoms like fever, fatigue, or unusual bruising, further evaluation may be warranted.

3. Need for Ultrasound:
- Given your slightly elevated direct bilirubin and the yellowing of your eyes, it may be prudent to consider an abdominal ultrasound. This imaging can help assess the liver's structure, check for gallstones, or identify any potential obstructions in the bile ducts.


Conclusion
In summary, while most of your liver function tests are within normal limits, the slightly elevated direct bilirubin and the yellowing of your eyes warrant further investigation. It would be beneficial to discuss these findings with your healthcare provider, who may recommend additional tests or imaging studies to ensure your liver health is optimal. Regular monitoring and a healthy lifestyle, including a balanced diet and avoiding excessive alcohol consumption, can also support liver function.

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