Managing Eye Pressure During Pregnancy: Concerns with Izba Use - Ophthalmology

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Using Izba Easy Pressure during pregnancy?


Hello everyone: Due to elevated intraocular pressure last year, there was a suspicion of glaucoma.
However, after evaluation by the doctor, it was determined that it is not glaucoma, but there are some issues with the optic nerve (which I am not very clear about).
I was prescribed Izba (brimonidine tartrate) to control the eye pressure, and since it has stabilized, I have been receiving long-term prescriptions.
Currently, I am 8 to 9 weeks pregnant, and I just learned during my appointment yesterday that this is a Category C medication.
I have already stopped the medication immediately, but since I have been using it for about eight to nine weeks, I would like to inquire if there are any cases of pregnant women inadvertently using similar medications, and what situations and risks I should be aware of moving forward? Thank you.

Wendy, 30~39 year old female. Ask Date: 2023/11/19

Dr. Gao Pilin reply Ophthalmology


Hello: The use of medications during pregnancy is very sensitive, especially in the early stages of fetal development (the first 12 weeks).
Izba (Eysu) is classified as a Category C drug, which means that animal studies have shown adverse effects on the fetus (teratogenic or embryotoxic), but there have been no controlled studies in pregnant women.
Therefore, it may not necessarily have an impact on pregnant women, and there is no need to be overly concerned.
You have already discontinued the use of this medication, but it is still important to seek professional advice from your ophthalmologist or obstetrician.

Reply Date: 2023/11/19

More Info


Managing eye pressure during pregnancy can be a complex issue, especially when it involves the use of medications like Izba (brimonidine tartrate), which is classified as a Category C drug. This classification indicates that animal studies have shown adverse effects on the fetus, but there are no well-controlled studies in pregnant women. Therefore, while there is potential risk, it does not guarantee that the drug will adversely affect every pregnant individual.

Given that you have been using Izba for approximately eight to nine weeks during your early pregnancy, it is understandable to be concerned about the implications for both your health and the health of your developing fetus. The first trimester is a critical period for fetal development, and exposure to certain medications can pose risks. However, it is important to note that the absence of controlled studies in humans means that the actual risk may vary.

Since you have already discontinued the use of Izba, it is advisable to consult with both your ophthalmologist and obstetrician to discuss your specific situation. They can provide tailored advice based on your medical history and current health status. Monitoring your eye pressure is crucial, especially since you have a history of elevated eye pressure and potential optic nerve issues. Your healthcare providers may suggest alternative treatments that are safer during pregnancy, such as topical medications that are classified as Category B, which have a better safety profile.

In terms of potential risks associated with the use of Izba during pregnancy, there are a few considerations. While the immediate effects of stopping the medication may not be apparent, it is essential to monitor for any changes in your eye pressure or vision. Elevated eye pressure can lead to complications, including damage to the optic nerve, which could affect your vision. Therefore, regular follow-ups with your eye doctor are important to ensure that your eye health remains stable.

Additionally, if you experience any unusual symptoms such as severe headaches, visual disturbances, or changes in your vision, it is crucial to seek medical attention promptly. These symptoms could indicate a need for further evaluation and management.

As for the broader context of managing eye pressure during pregnancy, it is worth noting that hormonal changes can influence eye health. Pregnant individuals may experience fluctuations in eye pressure due to changes in fluid dynamics and hormonal levels. Therefore, maintaining open communication with your healthcare team is vital to navigate these changes effectively.

In summary, while the use of Izba during early pregnancy raises valid concerns, the immediate step of discontinuing the medication is prudent. Collaborating with your healthcare providers will help you find a safe and effective management plan for your eye pressure while ensuring the well-being of both you and your baby. Regular monitoring and adjustments to your treatment plan may be necessary to balance the risks and benefits during this critical period.

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