Is It Normal to Have Genital Warts with Negative HPV Test Results? - Urology

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Having cauliflower-like lesions with a negative HPV test result is not uncommon. It is possible for such lesions to be caused by factors other than HPV, such as other infections or skin conditions. However, it is important to consult a healthcare professional for a thorough evaluation and appropriate management?


Hello Dr.
Du, I have diabetes and have been experiencing recurrent balanitis over the past few years.
At the beginning of last month, I consulted about a circumcision procedure.
The doctor diagnosed me with phimosis and noted that there were also several genital warts at the tip of the foreskin.
The circumcision procedure would allow for their removal as well.
At that time, I was unaware of what genital warts were, but after researching at home, I found out they are also known as condyloma.
I promptly arranged for the surgery and received the first dose of the nine-valent HPV vaccine.
Four weeks post-surgery, I thought I should not be infected with HPV, so I took an HPV test during my second vaccine dose appointment, and the result was negative.
The doctor mentioned that the vaccine might have suppressed the virus.
I would like to ask: 1.
Is it possible to have genital warts without the presence of HPV? 2.
Can the HPV virus really be suppressed by the vaccine to the point of disappearing so quickly, or was I never infected in the first place? 3.
I have already received two doses of the nine-valent vaccine and I am older than the recommended vaccination age; should I still receive the third dose?

Mr. Li, 40~49 year old female. Ask Date: 2023/11/26

Dr. Du Shixi reply Urology


Hello:
1.
Is it possible to have warts without HPV virus? --> It is possible that it was not detected.
If there is an infection, the test should show it.

2.
Does the HPV virus really get suppressed by the vaccine, and does it disappear so quickly? Or was there never an infection? --> This is beyond my explanation.

3.
I have already received two doses of the nine-valent vaccine, and I am older than the recommended age for vaccination.
Should I get a third dose? --> Please make your own decision.
The HPV vaccine has its benefits, but it is not mandatory.
Wishing you good health.

Reply Date: 2023/11/26

More Info


It’s understandable to have concerns regarding your health, especially when it comes to sexually transmitted infections (STIs) like HPV and the presence of genital warts. Let’s address your questions one by one, while also providing some additional context about HPV, genital warts, and vaccination.

1. Can you have genital warts without having HPV?
Genital warts, also known as condylomata acuminata, are caused by certain types of human papillomavirus (HPV), primarily the low-risk types such as HPV 6 and 11. If you have visible genital warts, it typically indicates that you have been infected with HPV. However, it is possible for HPV to be present at very low levels that might not be detected by standard HPV testing, especially if the test is designed to detect high-risk strains associated with cancer. Therefore, while it is uncommon, it is theoretically possible to have warts without a detectable HPV result, particularly if the testing was focused on high-risk types.

2. Can the HPV vaccine suppress the virus quickly?
The HPV vaccine is designed to protect against certain strains of HPV, particularly the high-risk types that can lead to cervical cancer and the low-risk types that cause genital warts. However, the vaccine does not eliminate existing infections. If you already have genital warts caused by HPV, the vaccine will not remove the virus from your system. It can, however, prevent future infections from the strains covered by the vaccine. The idea that the vaccine could "suppress" the virus is a misunderstanding; it is more accurate to say that the vaccine can help prevent new infections.

3. Should you receive the third dose of the HPV vaccine?
The HPV vaccination series typically consists of two or three doses, depending on your age at the time of vaccination. For individuals aged 15 and older, the standard recommendation is to receive three doses. Since you have already received two doses, it is advisable to complete the series with the third dose to ensure maximum protection against the strains of HPV that the vaccine covers. Even if you are beyond the recommended age for vaccination, it is still beneficial to complete the series, as it can provide additional protection.

In addition to addressing your specific questions, it is essential to consider the broader implications of HPV and genital warts on your health. Regular screenings, such as Pap smears and HPV tests, are crucial for monitoring cervical health, especially if you have a history of abnormal results or HPV-related conditions. Given your diabetes and history of infections, maintaining open communication with your healthcare provider is vital for managing your overall health and any potential complications.

Furthermore, while the presence of genital warts can be distressing, it is important to remember that many people with HPV do not experience any symptoms, and most will clear the virus from their systems over time. The immune system plays a significant role in controlling HPV infections, and many individuals will not develop any long-term health issues related to the virus.

In conclusion, while having genital warts typically indicates an HPV infection, the nuances of HPV testing and vaccination can lead to some confusion. Completing your vaccination series and maintaining regular health check-ups will help you manage your health effectively. If you have further concerns or questions, do not hesitate to reach out to your healthcare provider for personalized advice and support.

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