Post-Thyroidectomy Medication Management: Addressing Eltroxin Dosage Concerns - Surgery

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Postoperative medication issues after thyroid surgery?


Hello Dr.
Chen, I underwent a total thyroidectomy for a benign nodule in August of this year.
Post-surgery, I started taking one Eltroxin tablet daily.
After a month, blood tests showed symptoms of hypothyroidism (TSH 12 uIU/mL).
During my follow-up appointment, the doctor increased my dosage to 1.5 tablets of Eltroxin per day.
Two months later, I conducted a self-blood test (T4 8.5 µg/dL, TSH 0.126 uIU/mL) and exhibited signs of possible hyperthyroidism.
In this situation, without any special circumstances, should I continue taking 1.5 tablets of Eltroxin as a normal post-operative protocol, or should I temporarily stop taking Eltroxin to prevent worsening hyperthyroid symptoms until my next appointment? Thank you for your assistance, Dr.
Chen!

Xiao Zhi, 20~29 year old female. Ask Date: 2023/12/16

Dr. Chen Bingze reply Surgery


Hello, I suggest starting with one pill a day and then returning for a follow-up appointment to provide these data to your attending physician for adjustments.

Reply Date: 2023/12/16

More Info


After undergoing a total thyroidectomy, managing thyroid hormone replacement therapy, particularly with Eltroxin (levothyroxine), can be quite complex. Your situation, where you initially experienced hypothyroid symptoms (elevated TSH) and then later showed signs of hyperthyroidism (low TSH and elevated T4), is not uncommon. This fluctuation in thyroid hormone levels is often a result of the adjustments in medication dosage that are necessary after thyroid removal.

Firstly, it is important to understand that after a total thyroidectomy, the body no longer produces thyroid hormones, necessitating lifelong hormone replacement therapy. Eltroxin, which contains levothyroxine, is the standard treatment to restore normal thyroid hormone levels. The goal is to maintain TSH levels within the normal range, typically between 0.4 and 4.0 mIU/L, depending on individual circumstances.

In your case, the initial dose of Eltroxin was insufficient, as indicated by your elevated TSH levels (12 uIU/mL), which suggested hypothyroidism. The subsequent increase to 1.5 tablets daily appears to have been an appropriate response to your low thyroid hormone levels. However, the later blood test showing a TSH of 0.126 uIU/mL and a T4 of 8.5 µg/dL indicates that your thyroid hormone levels are now too high, leading to potential hyperthyroid symptoms.

When managing Eltroxin dosage, it is crucial to consider the following:
1. Monitoring and Adjustment: Regular monitoring of TSH and free T4 levels is essential after any dosage adjustment. It typically takes about 6-8 weeks after a dosage change for TSH levels to stabilize, so it’s important to allow time for the body to adjust before making further changes.

2. Dosage Reduction: Given your current lab results indicating hyperthyroidism, it would be prudent to discuss with your physician the possibility of temporarily reducing your Eltroxin dosage. Abruptly stopping the medication is generally not advisable, as this could lead to a return of hypothyroid symptoms. Instead, a gradual reduction may help stabilize your hormone levels.

3. Symptoms Monitoring: Pay close attention to any symptoms of hyperthyroidism, such as increased heart rate, anxiety, weight loss, or heat intolerance. If you experience these symptoms, it’s important to communicate them to your healthcare provider.

4. Consultation with Your Doctor: It’s crucial to have an open dialogue with your endocrinologist or the physician managing your thyroid hormone replacement therapy. They can provide personalized recommendations based on your lab results and symptoms. They may suggest a new dosage or additional tests to rule out other factors affecting your thyroid levels.

5. Lifestyle Considerations: Factors such as diet, medication interactions, and overall health can influence thyroid hormone levels. Ensure that you are taking Eltroxin on an empty stomach, ideally 30-60 minutes before breakfast, and avoid calcium or iron supplements within a few hours of taking the medication, as they can interfere with absorption.

In summary, while your current dosage of Eltroxin may have been appropriate initially, the recent lab results suggest that a dosage adjustment is necessary to avoid hyperthyroid symptoms. It is essential to work closely with your healthcare provider to find the right balance in your medication regimen. Regular follow-ups and lab tests will help ensure that your thyroid hormone levels remain stable and within the desired range.

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