Managing Bloating and Vomiting: Functional Gastrointestinal Disorders - Gastroenterology and Hepatology

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Abdominal distension and vomiting?


Hello Doctor, around July, I frequently experienced vomiting and was hospitalized for examinations, including an endoscopy, ultrasound, esophageal pressure testing, pH monitoring of the esophagus, gastric emptying study, and abdominal MRI.
Most results were normal, with only mild gastroesophageal reflux.
The doctor prescribed proton pump inhibitors and antiemetics, including Metoclopramide and Paracetamol.
However, the doctor recently concluded that I do not have any organic issues and suspects that my symptoms may be functional problems caused by stress and anxiety.
They switched my medication to Doxepin and the antiemetic Ondansetron.
Recently, I have been unable to eat my usual amount and feel bloated, and I may vomit shortly after.
I would like to ask how I should handle this situation.
Additionally, why would the doctor prescribe a tricyclic antidepressant for vomiting? How long does it typically take for tricyclic antidepressants to be effective? Is there a difference in the antiemetic effects between Metoclopramide and Ondansetron?

Hong, 30~39 year old female. Ask Date: 2023/12/20

Dr. Chen Shidian reply Gastroenterology and Hepatology


Please discuss the medication with the attending physician again.

Reply Date: 2023/12/20

More Info


Managing symptoms like bloating and vomiting can be quite challenging, especially when they stem from functional gastrointestinal disorders (FGIDs). FGIDs are conditions characterized by chronic gastrointestinal symptoms without any identifiable structural or biochemical abnormalities. In your case, it seems that after extensive testing, your healthcare provider has ruled out significant organic issues and is considering the role of stress and anxiety in your symptoms.


Understanding Functional Gastrointestinal Disorders
Functional gastrointestinal disorders can manifest in various ways, including bloating, nausea, vomiting, and changes in bowel habits. The symptoms can be exacerbated by stress, anxiety, and dietary choices. In your situation, the fact that you have experienced vomiting and bloating after meals suggests that your gastrointestinal tract may be reacting to stress or anxiety, which can lead to increased sensitivity and altered motility.


Treatment Options
1. Medications: Your doctor has prescribed proton pump inhibitors (PPIs) like 胃明朗 (Gastric acid suppressants) and antiemetics like 摩暢膜衣錠 (anti-nausea medication). These medications can help manage symptoms by reducing stomach acid and controlling nausea. However, it’s important to note that while PPIs can help with acid-related symptoms, they may not address the underlying functional issues.

2. Antidepressants: The use of tricyclic antidepressants (TCAs) for managing FGIDs is well-documented. These medications can help modulate gut sensitivity and improve motility. They are often prescribed at lower doses than those used for treating depression. The time frame for noticing improvements can vary; typically, it may take several weeks (4-6 weeks) to see significant benefits. The mechanism by which TCAs help is not entirely understood, but they may alter the perception of pain and improve gastrointestinal function.

3. Dietary Modifications: Keeping a food diary can help identify any dietary triggers that may exacerbate your symptoms. Eating smaller, more frequent meals rather than large meals can also help reduce bloating and discomfort. Additionally, avoiding known irritants such as caffeine, alcohol, and spicy foods may be beneficial.

4. Stress Management: Since your symptoms may be linked to stress and anxiety, incorporating stress-reduction techniques such as mindfulness, yoga, or cognitive behavioral therapy (CBT) can be helpful. These approaches can help manage anxiety and improve your overall well-being, which may, in turn, alleviate gastrointestinal symptoms.

5. Follow-Up: Regular follow-ups with your healthcare provider are essential. If your symptoms persist despite treatment, further evaluation may be necessary. This could include additional tests or a referral to a gastroenterologist specializing in functional disorders.


Comparing Anti-Nausea Medications
Regarding the effectiveness of 胃明朗 and 摩暢膜衣錠, while both are used to manage nausea, they work through different mechanisms. 胃明朗 is primarily a PPI that reduces stomach acid, which can help with nausea related to acid reflux. In contrast, 摩暢膜衣錠 may work more directly on the gut to reduce nausea and improve motility. Your healthcare provider can help determine which medication is more appropriate based on your specific symptoms.


Conclusion
In summary, managing bloating and vomiting related to functional gastrointestinal disorders involves a multifaceted approach that includes medication, dietary changes, stress management, and regular follow-up care. It’s crucial to communicate openly with your healthcare provider about your symptoms and any concerns you may have regarding your treatment plan. With the right strategies in place, many individuals with FGIDs can find relief and improve their quality of life.

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