Do Oral Nystatin and Emergency Contraceptives Interact? - Obstetrics and Gynecology

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The interaction between emergency contraceptive pills and oral nystatin?


Due to a Candida infection, the obstetrician prescribed oral nystatin and vaginal nystatin suppositories.
Since oral nystatin is an antifungal medication, I would like to know if it interacts with the Yaz birth control pill, potentially reducing its effectiveness.
My second question is, if my boyfriend is only wearing underwear and I am wearing both underwear and pants, is there a risk of pregnancy from genital friction? Thank you, doctor.

Betty, 20~29 year old female. Ask Date: 2024/01/01

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, there should be no mutual influence, so pregnancy is unlikely.
Wishing you good health.

Reply Date: 2024/01/01

More Info


When it comes to the interaction between oral Nystatin and emergency contraceptives, it is important to clarify a few points regarding their mechanisms of action and potential interactions. Nystatin is an antifungal medication primarily used to treat fungal infections, particularly those caused by Candida species, such as oral thrush or vaginal yeast infections. It works by binding to ergosterol in the fungal cell membrane, leading to cell death. On the other hand, emergency contraceptives, such as the one you mentioned (which contains ethinylestradiol and gestodene), work primarily by preventing ovulation, inhibiting fertilization, or preventing implantation of a fertilized egg.

Based on current medical knowledge, there is no evidence to suggest that oral Nystatin interacts with emergency contraceptives in a way that would diminish their effectiveness. Nystatin does not have any known effects on the hormonal pathways that emergency contraceptives utilize to prevent pregnancy. Therefore, you can take oral Nystatin while using emergency contraceptives without worrying about a reduction in the contraceptive's effectiveness.

However, it is always advisable to inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements, to ensure comprehensive care and monitoring for any potential interactions.

Regarding your second question about the risk of pregnancy due to genital friction while wearing underwear, it is important to understand how pregnancy occurs. Pregnancy typically requires the presence of sperm that can fertilize an egg. For this to happen, sperm must be deposited in the vaginal canal, which usually occurs through sexual intercourse.
In your scenario, if both you and your boyfriend are wearing underwear and there is only external genital contact (friction through clothing), the likelihood of sperm being transferred to the vaginal area is extremely low. Sperm are not able to swim effectively through clothing, and the barrier of fabric significantly reduces the chances of sperm reaching the vagina. While it is theoretically possible for sperm to be transferred if there were any direct contact with pre-ejaculatory fluid (which can contain sperm), the risk remains very low in the situation you described.

In summary, you can safely use oral Nystatin alongside emergency contraceptives without concern for interaction. Additionally, the risk of pregnancy from genital friction while both parties are clothed is minimal. However, if you have further concerns about your specific situation or any other health-related questions, it is always best to consult directly with your healthcare provider for personalized advice and guidance.

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