Do These Medications Interact with My Allergy Treatment? - Pharmacology

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Inquire whether there are any drug interactions?


Hello, doctor.
Recently, I received treatment for skin allergies at the dermatology department, which included 10 mg of A acid, Allegra (fexofenadine) pink tablets, and a coated tablet called Suprastin.
Will these medications affect the efficacy of the premedication I am taking, which is Loryna (drospirenone and ethinyl estradiol)? Thank you, doctor.

Kk, 10~19 year old female. Ask Date: 2024/01/02

Dr. Hou Fangmin reply Pharmacology


Hello, Kk: The concurrent use of isotretinoin (A acid) 10 mg, Allegra (fexofenadine), levocetirizine, isotretinoin, and norethindrone acetate combined with ethinyl estradiol may affect the effectiveness of the hormonal contraceptive.
Research indicates that the concurrent use of isotretinoin and hormonal contraceptives may result in decreased effectiveness of the hormonal contraceptives.
Therefore, please be cautious regarding the use of isotretinoin and norethindrone acetate together, as it may reduce the effectiveness of norethindrone acetate.
Wishing you peace and health in the new year.

Reply Date: 2024/01/02

More Info


When considering the potential interactions between the medications you are taking for your allergy treatment and your oral contraceptive, it is essential to understand how these drugs work and their pharmacological profiles.
You mentioned that you are taking A酸 (Tretinoin) 10 mg, Allegra (Fexofenadine), and a medication called 服敏優膜衣錠 (which I assume is a form of antihistamine or allergy medication). You also mentioned that you are on an oral contraceptive called 洛依欣 (Loestrin, a combination of ethinyl estradiol and norethindrone).
1. Tretinoin (A酸): This medication is primarily used topically for acne and skin conditions. It works by promoting cell turnover and preventing the formation of new acne lesions. Since it is applied to the skin and not taken orally, it does not have systemic effects that would interact with your oral contraceptive. Therefore, it should not affect the efficacy of your birth control.

2. Allegra (Fexofenadine): This is a second-generation antihistamine used to treat allergic symptoms such as sneezing, runny nose, and itchy eyes. Fexofenadine is not known to have any significant interactions with hormonal contraceptives. Studies have shown that antihistamines do not affect the metabolism of contraceptive hormones, so you can take Allegra without worrying about it impacting the effectiveness of your birth control.

3. 服敏優膜衣錠: Without knowing the exact composition of this medication, it is challenging to provide a definitive answer. However, if it is another antihistamine or an allergy medication, it is likely to have a similar profile to Allegra. Most allergy medications do not interact with hormonal contraceptives, but it is always best to check the specific ingredients.

In summary, based on the medications you listed, there is no evidence to suggest that they would interfere with the effectiveness of your oral contraceptive, 洛依欣. However, it is essential to consider the following:
- Consult Your Healthcare Provider: Always discuss any new medications or changes in your health regimen with your healthcare provider or pharmacist. They can provide personalized advice based on your complete medical history and current medications.


- Monitor for Side Effects: While interactions may not be a concern, it is still important to monitor how you feel while taking these medications together. If you experience any unusual symptoms or side effects, report them to your healthcare provider.

- Adherence to Medication: Ensure that you are taking your medications as prescribed. Consistency is key in maintaining the effectiveness of both your allergy treatment and your contraceptive method.

In conclusion, the medications you are currently taking for your allergy treatment should not negatively impact the effectiveness of your oral contraceptive. However, maintaining open communication with your healthcare provider is crucial for your overall health and safety.

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