Elevated PSA Levels: Causes and Concerns - Urology

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Elevated PSA levels?


My prostate-specific antigen (PSA) levels have been steadily increasing over the years, and last week it reached 30.
I have undergone four biopsies at Asia University Hospital, all of which were normal.
However, the continuous rise in this index is concerning.
The doctor mentioned that either a transurethral resection of the prostate (TURP) could lower the levels, and it would also help determine if there is any prostate cancer.
I also have obstructive sleep apnea; could this condition be causing an inflammatory response in my body, leading to the persistent increase in PSA levels?

Chen Kai, 70~79 year old female. Ask Date: 2024/01/05

Dr. Li Minghui reply Urology


Hello: A rise to 30 can be primarily attributed to inflammation or cancer.
If you are open to it, I recommend seeking a second opinion at a medical center, as some physicians are more specialized in this area.
Wishing you good health.

Reply Date: 2024/01/05

More Info


Elevated PSA (Prostate-Specific Antigen) levels can be a source of concern for many men, particularly as they age. Understanding the causes of elevated PSA levels and the implications for prostate health is crucial for making informed decisions about further testing and treatment options.

PSA is a protein produced by both normal and malignant cells of the prostate gland. While it is primarily used as a marker for prostate cancer, elevated PSA levels can also be influenced by a variety of non-cancerous conditions. These include benign prostatic hyperplasia (BPH), prostatitis (inflammation of the prostate), urinary tract infections, and even recent sexual activity or certain medical procedures. For instance, activities such as vigorous exercise, particularly cycling, can temporarily raise PSA levels due to increased pressure on the prostate.

In your case, with a PSA level that has been consistently rising and having undergone multiple biopsies that returned normal results, it is understandable to feel anxious. The fact that your PSA levels have reached 30 is significant and warrants careful monitoring. While benign conditions can cause elevated PSA levels, such a high reading often raises the suspicion of prostate cancer, especially if there are no other identifiable causes.

Regarding your question about sleep apnea, there is emerging evidence suggesting that sleep apnea may be associated with increased inflammation in the body, which could potentially contribute to elevated PSA levels. Chronic inflammation is known to affect prostate health, and men with sleep apnea may experience a variety of health issues that could indirectly influence PSA levels.

When faced with elevated PSA levels, the next steps typically involve a thorough evaluation. This may include repeated PSA testing to monitor trends over time, imaging studies such as MRI, and possibly a prostate biopsy if there is a persistent elevation without a clear benign cause. The decision to proceed with a biopsy should be made in consultation with a urologist, who can assess your individual risk factors, family history, and overall health.

If your doctor has suggested a procedure such as a transurethral resection of the prostate (TURP) to help manage your symptoms and potentially lower your PSA levels, it is important to weigh the benefits and risks. TURP can alleviate urinary symptoms associated with BPH, but it is not a definitive treatment for prostate cancer. If cancer is suspected, further evaluation is necessary to confirm the diagnosis.

In terms of lifestyle modifications, maintaining a healthy diet, regular exercise, and managing stress can be beneficial for overall prostate health. Some studies suggest that a diet low in saturated fats and high in fruits and vegetables may help reduce the risk of prostate issues. Additionally, staying hydrated and avoiding irritants such as caffeine and alcohol can support urinary health.

Lastly, it is essential to address any anxiety or stress related to your health concerns. Consider discussing your feelings with a healthcare professional, as they can provide support and resources to help manage anxiety. Mental health is an important aspect of overall well-being, especially when dealing with chronic health issues.

In summary, elevated PSA levels can be caused by various factors, and while they can indicate potential health issues, they do not always mean cancer is present. Continuous monitoring, lifestyle adjustments, and open communication with your healthcare provider are key to managing your prostate health effectively.

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