Do Finasteride and Topiramate Affect Eye Pressure? - Ophthalmology

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Drug interactions


Hello, doctor.
Recently, I have been experiencing high intraocular pressure, and my physician prescribed Medison's eye drops for pressure control.
I am currently taking finasteride for male pattern baldness and topiramate prescribed by a neurologist.
Could you please let me know if these two medications will affect my high intraocular pressure? Thank you.

Xiao Ping, 40~49 year old female. Ask Date: 2024/01/22

Dr. Liang Ce reply Ophthalmology


I recommend that you: 1.
Discuss the above situation further with your attending physician.
2.
Consider consulting an ophthalmologist at a major hospital.
Wishing you good health.
Thank you!

Reply Date: 2024/01/22

More Info


Finasteride and Topiramate are two medications that serve different purposes, and their effects on eye pressure are important to consider, especially in the context of managing conditions like glaucoma or elevated intraocular pressure (IOP).

Finasteride is primarily used to treat benign prostatic hyperplasia (BPH) and male pattern baldness (androgenetic alopecia). It works by inhibiting the enzyme 5-alpha-reductase, which converts testosterone to dihydrotestosterone (DHT). There is limited evidence to suggest that Finasteride has a direct effect on intraocular pressure. Most studies indicate that it does not significantly affect eye pressure levels. However, individual responses can vary, and it is always advisable to monitor any changes in eye health when starting a new medication.

Topiramate, on the other hand, is an anticonvulsant medication that is also used to prevent migraines. One of the notable side effects of Topiramate is that it can cause secondary angle-closure glaucoma, which is a condition that can lead to increased intraocular pressure. This side effect is particularly concerning for patients who may already be at risk for glaucoma or have elevated eye pressure. Symptoms of this condition can include sudden vision changes, eye pain, headache, and nausea. If you are taking Topiramate and experience any of these symptoms, it is crucial to seek medical attention promptly.

Given your current situation of elevated eye pressure and the medications you are taking, it is essential to communicate with your healthcare provider about your concerns. They can help assess the risks and benefits of continuing these medications in the context of your eye health. Regular eye examinations and monitoring of intraocular pressure are vital, especially if you are on medications that could potentially affect your eye pressure.

In summary, while Finasteride is not known to significantly impact eye pressure, Topiramate can potentially lead to increased intraocular pressure and should be used with caution in individuals with a history of eye problems. Always consult your healthcare provider for personalized advice and to discuss any changes in your medications or eye health. Regular follow-ups with an eye specialist can help ensure that any potential issues are identified and managed early, reducing the risk of complications related to elevated eye pressure or glaucoma.

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