Yellowing of the Eye: When to Worry About Liver Health - Ophthalmology

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Sclera of the right eye


Hello, doctor.
I would like to ask about a slight yellowing in the sclera of my right eye.
Is this normal? My left eye does not have this issue; only the lower part of the sclera in my right eye appears yellow.
Could this be related to my previous frequent use of eye drops? Thank you.
Also, I've heard that yellowing of the sclera can indicate liver problems.
How can I differentiate between normal yellowing and that which indicates liver issues?

Xiao Zhe, 30~39 year old female. Ask Date: 2024/03/07

Dr. Gao Pilin reply Ophthalmology


Hello: The statement regarding the yellowing of the sclera being related to liver function typically refers to jaundice.
However, yellowing of the sclera does not necessarily indicate a liver problem, as there are various other causes, such as conjunctival pigmentation.
Jaundice typically causes both eyes to exhibit yellow sclera, and if the sclera is yellow, there are usually other symptoms present, such as tea-colored urine.
A slight yellowing of the lower sclera in the right eye is likely not indicative of liver-related jaundice.
For a detailed diagnosis, it is advisable to consult an ophthalmologist.

Reply Date: 2024/03/07

More Info


The yellowing of the eyes, particularly the sclera (the white part of the eye), is a condition known as jaundice. It can be indicative of underlying health issues, particularly related to liver function. However, it is essential to understand that not all yellowing of the eyes is due to liver problems.
In your case, you mentioned that only the lower part of the sclera in your right eye appears slightly yellow, while the left eye remains unaffected. This localized yellowing could be due to several factors, including but not limited to:
1. Conjunctival Injection: This is a condition where the blood vessels in the conjunctiva (the membrane covering the sclera) become dilated, leading to a reddish or yellowish appearance. This can happen due to allergies, irritants, or prolonged use of eye drops.

2. Pterygium or Pinguecula: These are growths on the conjunctiva that can appear yellowish. They are often benign and can be caused by UV exposure, dry eyes, or irritation.

3. Liver Function: While jaundice is often associated with liver dysfunction, it typically presents with a more pronounced yellowing of the sclera and skin. If your liver function tests (like AST and ALT) are normal, as indicated in previous discussions, it is less likely that your yellowing is related to liver disease.

4. Eye Drops: Frequent use of certain eye drops can lead to changes in the appearance of the sclera. Some drops may cause irritation or allergic reactions, leading to redness or discoloration.

To determine whether the yellowing of your eye is a cause for concern, consider the following steps:
- Monitor Symptoms: If you experience additional symptoms such as fatigue, dark urine, pale stools, or abdominal pain, it may warrant further investigation into liver function.

- Consult an Eye Specialist: An ophthalmologist can provide a thorough examination to rule out any eye-related issues that may be causing the yellowing.

- Liver Function Tests: If you have not had recent liver function tests, it may be beneficial to have these done to ensure your liver is functioning properly.

- Family History: Since you mentioned a family history of liver issues, it is prudent to keep this in mind and discuss it with your healthcare provider.

In summary, while yellowing of the eyes can be a sign of liver problems, localized yellowing in one eye may not necessarily indicate a serious issue. It is essential to consider other factors, including eye health and any accompanying symptoms. Regular check-ups with your healthcare provider and an eye specialist can help ensure that any potential issues are addressed promptly. If you have concerns about your liver health, discussing them with your doctor and possibly undergoing further testing would be advisable.

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