Computed Tomography Interpretation
A female patient, non-smoker and non-drinker, with no history of hepatitis B or C, has undergone health check-ups in 2013, 2018, and 2022.
She has three hemangiomas in the liver that are being monitored regularly.
On February 19 of this year, she went to Cheng Ching Hospital for a CT scan to follow up on the hemangiomas.
Her alpha-fetoprotein (AFP) levels have been consistently around 13 since 2013, which is slightly elevated, but the doctor indicated that this is congenital.
During her recent follow-up, the doctor reported finding a new tumor measuring 4.6 cm.
She has an appointment with surgery scheduled for March 22.
Upon reviewing the pathology report uploaded to the health insurance system, it states that it is HCC (hepatocellular carcinoma) T1b M0, while all other markers are normal.
Is it possible that this tumor developed between November 22, 2022, and February 19, 2024? Given that I am not considered a high-risk group, how could I have liver cancer? Additionally, I would like to note that I sought to monitor the hemangiomas purely for follow-up purposes, and I have not experienced any physical discomfort.
Thank you.
Qiu Xiaojie, 40~49 year old female. Ask Date: 2024/03/08
Dr. Chen Shidian reply Gastroenterology and Hepatology
If liver biopsy has confirmed the diagnosis, proceed with surgery as soon as possible.
If a liver biopsy has not yet been performed, discuss the treatment plan with the attending physician.
Liver cancer can still occur (though very rarely) in the general population without hepatitis B infection.
Reply Date: 2024/03/08
More Info
Understanding the implications of CT scan results, especially in the context of liver tumors and hepatocellular carcinoma (HCC), is crucial for patients and their families. Based on your situation, it appears you have a history of benign hemangiomas in the liver, which have been monitored over the years. However, the recent discovery of a new tumor measuring 4.6 cm raises several important questions regarding its nature and the potential implications for your health.
Firstly, the presence of a new tumor that has developed between your last imaging in November 2022 and your recent scan in February 2024 suggests that this lesion is indeed new. The pathology report indicating HCC (T1b M0) means that the tumor is localized (T1b) and has not metastasized (M0). This classification is significant as it informs the staging and potential treatment options. HCC is often associated with underlying liver disease, such as cirrhosis or chronic hepatitis, but you mentioned that you do not have these risk factors, which is somewhat atypical.
The fact that you are not in a high-risk group for liver cancer yet have developed HCC can be perplexing. While certain risk factors such as chronic viral hepatitis, alcohol abuse, and metabolic liver diseases significantly increase the risk of HCC, there are cases where liver cancer can develop in individuals without these traditional risk factors. Genetic predispositions, environmental exposures, and other less understood factors may contribute to the development of HCC in otherwise healthy individuals.
Regarding your alpha-fetoprotein (AFP) levels, while a stable level of around 13 may not be alarming, it is essential to note that AFP can sometimes be elevated in liver cancer, although it is not exclusively indicative of malignancy. In some cases, individuals may have elevated AFP levels due to benign liver conditions or even due to genetic factors, as your doctor suggested.
As for the management of your newly diagnosed HCC, treatment options may vary based on several factors, including the tumor size, liver function, and overall health. Surgical resection, liver transplantation, and local ablative therapies (like radiofrequency ablation) are common approaches for early-stage HCC. Given that your tumor is classified as T1b, surgical options may still be viable, but this will depend on the assessment of your liver function and the presence of any underlying liver disease.
It is also important to consider follow-up imaging and possibly further diagnostic procedures to assess the tumor's characteristics and to monitor for any additional lesions. Regular follow-up with imaging studies, such as CT or MRI, will be essential in managing your condition.
In summary, while the discovery of a new liver tumor can be alarming, understanding its nature, the implications of the pathology report, and the absence of traditional risk factors can provide a clearer picture of your health. It is crucial to have an open dialogue with your healthcare team, including a hepatologist or oncologist, to discuss the best management strategies tailored to your specific situation. Regular monitoring and proactive management will be key in addressing this new diagnosis and ensuring the best possible outcomes.
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