Skin Biopsy Results: What Does a Cutaneous Horn Mean? - Dermatology

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Please assist in explaining the biopsy report?


Hello Doctor: Below is my grandmother's skin biopsy report.
Since she has mobility issues and needs to wait for a long-term care vehicle appointment to return for a follow-up, we are unsure when that will happen.
Therefore, I would like to ask about the results.
Is there any urgency or severity?
Skin, nose, shaving, cutaneous horn.
The specimen submitted consists of a skin nodule, measuring 1.3 x 0.9 x 0.6 cm, grayish-brown and soft elastic, fixed in formalin.
All for section.
Jar 0.
Histological sections reveal a picture of a cutaneous horn.
The covering squamous epithelium shows marked hyperkeratosis and parakeratosis, along with acanthosis, elongation of rete pegs, and is consistent with a cutaneous horn.
It is compatible with a cutaneous horn.
A special stain is recommended for fungal infection.

Xiao Lan, 90~99 year old female. Ask Date: 2024/03/08

Dr. Wu Yuxin reply Dermatology


First, I am not your grandmother's attending physician, so I do not have the authority to explain her medical condition.
Second, patients have a right to privacy, and it is neither appropriate nor permissible for you to discuss someone else's medical condition in a public forum.
It is still advisable to obtain information about the patient's illness through the proper channels.

Reply Date: 2024/03/08

More Info


A cutaneous horn, as indicated in your grandmother's skin biopsy report, is a type of skin lesion that appears as a hard, conical projection from the skin. It is primarily composed of keratin, the same protein that makes up hair and nails. The presence of a cutaneous horn can be associated with various underlying skin conditions, ranging from benign to malignant.

The biopsy report describes the specimen as a skin nodule measuring 1.3 x 0.9 x 0.6 cm, with a grayish-brown color and soft elastic texture. The histological findings show marked hyperkeratosis (thickening of the outer layer of the skin), parakeratosis (retention of nuclei in the stratum corneum), and acanthosis (thickening of the skin). These findings are consistent with a cutaneous horn. The elongation of rete pegs, which are projections of the epidermis into the dermis, further supports this diagnosis.

While cutaneous horns are often benign, they can sometimes be associated with underlying skin conditions, including actinic keratosis, squamous cell carcinoma, or other forms of skin cancer. The recommendation for special staining to check for fungal infection suggests that the pathologist is considering the possibility of a secondary infection or other dermatological conditions that may need to be ruled out.

In terms of urgency or severity, it is essential to consider the context of the lesion. If the cutaneous horn is associated with a benign condition, it may not require immediate intervention. However, if there is any suspicion of malignancy, further evaluation and possibly treatment would be warranted. It is crucial to follow up with a dermatologist or the healthcare provider who ordered the biopsy for a comprehensive assessment and to discuss the next steps.

In the meantime, here are some general points regarding cutaneous horns and skin health:
1. Monitoring Changes: Keep an eye on the cutaneous horn for any changes in size, color, or texture. Any rapid changes should prompt immediate medical attention.

2. Sun Protection: Since many skin lesions can be exacerbated by sun exposure, it is advisable to use sunscreen and protective clothing to minimize UV damage.

3. Skin Care: Maintaining healthy skin through proper hydration and moisturizing can help support overall skin health. However, avoid any aggressive treatments or products on the affected area until a healthcare provider has assessed it.

4. Follow-Up: Given your grandmother's mobility issues, it may be helpful to explore options for telemedicine consultations or home visits by healthcare professionals to ensure she receives timely care.

5. Potential Treatments: Depending on the final diagnosis, treatment options may vary. If the cutaneous horn is benign, it may simply be monitored. If it is associated with a more serious condition, treatments could range from topical therapies to surgical excision.

In conclusion, while the presence of a cutaneous horn can be concerning, the specific implications depend on the underlying pathology. It is essential to consult with a healthcare provider for a thorough evaluation and to discuss the biopsy results in detail.

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