Sperm Morphology Changes: From 1% to 81% in Semen Analysis - Urology

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Abnormal sperm morphology increased from 1% to 81%?


I would like to ask Dr.
Fu about our active attempts to conceive for 7 months without success.
For 4 of those months, we recorded ovulation dates by counting back 14 days from the start of my menstrual cycle, and we had intercourse during those times, but still no pregnancy.
Therefore, we went to a fertility clinic for testing.
The female partner's AMH level is 3.18, and a vaginal ultrasound showed normal endometrial thickness and a normal number of mature follicles.
On March 2, the male partner underwent a semen analysis at the fertility clinic with the following results: Total volume: 2.6 ml, Sperm count: 130 million, Rapid Progressive (Type A): 48.4%, Medium Progressive (Type B): 9.2%, Non-Progressive (Type C): 4.6%, Immotile (Type D): 37.8%, Total motility: 62.2%, Liquefaction: Normal, Morphology: Normal: 2% (1%), Abnormal: 198% (99%), with head defects 195, midpiece defects 3, tail defects 0, and cytoplasmic droplets 0.

Due to the morphology issues, we consulted a urologist who suggested repeating the semen analysis for better assessment.
Therefore, on March 18, another test was conducted with the following results: pH 8.0, Volume: 5 ml, Count: 42 million, Morphology: 81%, Normal Motility: 71% after 60 minutes, WBC: 1-2.
Both tests were done after 4 days of abstinence, but the results varied significantly, especially the sperm morphology, which changed from 1% in the first test to 81% in the second, despite no changes in lifestyle.

Could you please advise if such discrepancies in test results are normal or what might cause them? Should we consider a third test or repeat the first or second tests? Or do you have any other recommendations? Thank you!

GG, 30~39 year old female. Ask Date: 2024/03/20

Dr. Fu Shizhang reply Urology


You may consider undergoing a re-examination.

Reply Date: 2024/03/20

More Info


Understanding the changes in sperm morphology and overall semen analysis results can be quite complex, especially when there are significant differences between tests conducted in a short period. Your situation, where the sperm morphology changed dramatically from 1% to 81% normal forms, raises several important points to consider.

Firstly, it is essential to understand that sperm morphology refers to the size and shape of sperm cells. Normal morphology is crucial for fertility, as abnormal shapes can affect the sperm's ability to fertilize an egg. The World Health Organization (WHO) defines normal sperm morphology as having at least 4% of sperm with a normal shape. In your first test, with only 1% normal morphology, this would typically indicate a significant concern regarding fertility potential. However, the subsequent test showing 81% normal morphology suggests a remarkable improvement.

Several factors could contribute to the differences in results between the two semen analyses:
1. Sample Collection and Handling: The method of collection can significantly impact the results. For instance, if the first sample was collected in a way that exposed it to certain chemicals or if it was not handled properly before analysis, it could lead to skewed results. The second sample, collected under more controlled conditions, may have yielded more accurate results.

2. Time and Abstinence: The duration of abstinence before ejaculation can also affect sperm quality. While you mentioned that both tests had a 4-day abstinence period, individual physiological responses can vary. The sperm production cycle is approximately 64-72 days, and factors such as stress, illness, or changes in lifestyle can impact sperm quality during this time.

3. Health and Lifestyle Factors: Changes in diet, exercise, stress levels, and overall health can influence sperm parameters. If there were any changes in these areas between the two tests, they could account for the differences observed.

4. Laboratory Variability: Different laboratories may use different techniques and reference values, which can lead to variability in results. It is crucial to ensure that the same laboratory performs follow-up tests for consistency.

5. Underlying Medical Conditions: If there are any underlying medical conditions affecting sperm production or morphology, these may fluctuate over time. Conditions such as infections, hormonal imbalances, or varicocele can impact sperm quality.

Given these factors, it is advisable to discuss the results with your healthcare provider. They may recommend further testing or a repeat analysis at the same laboratory to confirm the findings. Additionally, if there are concerns about sperm morphology or other parameters, a urologist or fertility specialist can provide further evaluation and potential treatment options.

In terms of next steps, consider the following:
- Repeat Testing: If there is still uncertainty, repeating the semen analysis at the same lab could provide clarity. Ensure that the sample is collected under optimal conditions.

- Lifestyle Modifications: Focus on maintaining a healthy lifestyle, including a balanced diet, regular exercise, and stress management, as these can positively influence sperm health.

- Consult a Specialist: If you have not already, consulting a fertility specialist can provide more tailored advice and potential interventions, especially if you continue to experience difficulties in conceiving.

In conclusion, while the initial low morphology result was concerning, the subsequent improvement is encouraging. It is essential to continue monitoring and addressing any potential factors that could affect fertility. Open communication with your healthcare provider will be key in navigating this journey.

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