Side Effects of Levothyroxine in Hypothyroidism Treatment - Internal Medicine

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Thyroid medication consultation


I have hypothyroidism (Hashimoto's disease) and have been under follow-up for over two years with no significant symptoms.
During my last follow-up in March, my levels worsened slightly, and my doctor prescribed Eltroxin 50, instructing me to take half a tablet daily.
Starting on the third day of taking it, I developed a sore throat, which I initially thought was a cold.
However, it has been ten days now, and I still only have a sore throat, so it doesn't seem to be a cold.
I would like to know if this could be a side effect of Eltroxin, and whether I should continue taking it.

Jessie, 40~49 year old female. Ask Date: 2024/03/24

Dr. Li Jian reply Internal Medicine


The dosage of Antithyroid medication needs to be monitored by blood tests for TSH and free T4 levels in order to determine the appropriate dosage.
Thank you for your inquiry.

Reply Date: 2024/03/24

More Info


Levothyroxine, commonly known by its brand name Synthroid or Eltroxin (昂特欣), is a synthetic form of the thyroid hormone thyroxine (T4) used to treat hypothyroidism, a condition where the thyroid gland does not produce enough hormones. While Levothyroxine is generally well-tolerated, it can cause side effects in some individuals, particularly when the dosage is not properly adjusted.

In your case, you have been taking Levothyroxine for about ten days and are experiencing a sore throat. It is important to note that while sore throat is not a commonly reported side effect of Levothyroxine, it can occur due to several reasons. One possibility is that the sore throat may be unrelated to the medication and could be due to a viral infection or another underlying condition. However, it is also possible that the medication could be contributing to your symptoms, particularly if you are experiencing other signs of thyroid hormone imbalance.

Levothyroxine can cause side effects if the dosage is too high, leading to symptoms of hyperthyroidism, such as increased heart rate, anxiety, weight loss, and heat intolerance. However, a sore throat is not a typical symptom of hyperthyroidism. It is crucial to monitor your symptoms closely and communicate with your healthcare provider about any new or worsening symptoms you experience while on the medication.

If you suspect that the sore throat is a side effect of Levothyroxine, it is essential to consult your doctor. They may recommend adjusting your dosage or switching to a different formulation. It is not advisable to stop taking Levothyroxine without consulting your healthcare provider, as this could lead to a return of hypothyroid symptoms, which can include fatigue, weight gain, depression, and sensitivity to cold.

In addition to medication, managing hypothyroidism often involves regular monitoring of thyroid hormone levels through blood tests. Your healthcare provider will typically check your TSH (thyroid-stimulating hormone) and T4 levels to ensure that your dosage is appropriate. If your levels are not within the desired range, your doctor may adjust your dosage accordingly.

In terms of dietary and lifestyle considerations, ensure you are consuming a balanced diet rich in nutrients that support thyroid health. Foods high in iodine, selenium, and zinc can be beneficial. However, be cautious with supplements, as excessive iodine can interfere with thyroid function. It is also advisable to avoid certain foods that can inhibit thyroid hormone absorption, such as soy products and high-fiber foods, when taking Levothyroxine.

In summary, while Levothyroxine is an effective treatment for hypothyroidism, it is essential to monitor for side effects and communicate any concerns with your healthcare provider. If your sore throat persists or worsens, seek medical advice to determine the appropriate course of action. Your doctor may recommend continuing the medication with adjustments or exploring alternative treatments based on your specific needs and health status.

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