Can X-rays or CT Scans Differentiate Causes of Sacroiliitis? - Internal Medicine

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Can X-rays or CT scans differentiate the causes of sacroiliac joint arthritis? What are the treatment options for enthesitis?


Hello Doctor, I have been experiencing chronic lower back pain that alleviates with activity.
X-rays from last year show bilateral grade II sacroiliitis, and I have peripheral arthritis (two fingers on my left hand last year), HLA-B27 positive, and enthesitis.
Recently, my doctor suspects I may have ankylosing spondylitis (AS), and a CT scan has been arranged for confirmation.
I have a few questions:
(1) My right ankle has had intermittent sharp pain since last year, feeling like it’s being bitten, with increased pain at night.
Additionally, I have persistent soreness on the outer side of my right hip, which feels tight where it contacts my pants.
However, neither area appears red, swollen, or hot like my fingers did last year during inflammation.
Does this resemble enthesitis? I have been receiving shortwave and ultrasound heat therapy at a rehabilitation clinic, but the treatment has made my ankle pain worse, although my groin discomfort is temporarily relieved.
(2) I have been taking two Salazopyrin and one Celebrex for two weeks, which has significantly improved my back pain, but there has been no improvement in my ankle and hip issues.
The rehabilitation clinic has suggested injection therapies like prolotherapy with glucose; is this appropriate?
(3) Can X-rays or CT scans differentiate whether sacroiliitis is due to chronic inflammation or injury? I have read that sacroiliitis seems to be quite common.
My pain points, aside from my back and buttocks, shift bilaterally, with my ankle and hip pain localized to the right side.
Over the past year, I have had three blood tests with normal ESR and CRP levels.
I genuinely suspect that improper long-term exercise may have caused sacroiliac joint misalignment.
Would it be advisable to try massage therapy for realignment?

Kate, 50~59 year old female. Ask Date: 2024/05/22

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your inquiry.
Here are my responses:
(1) I have been experiencing intermittent sharp pain in my right ankle since last year, as if it is being bitten, with the pain intensifying at night.
Additionally, I have long-term soreness on the outer side of my right hip, which feels tight where it contacts my pants.
However, neither of these areas appears red, swollen, or hot like my fingers did last year during inflammation.
Could this be related to enthesitis? I have been undergoing shortwave and ultrasound heat therapy at a rehabilitation clinic, but the treatment has increased the pain in my ankle while providing temporary relief for my groin.
--> The pain in your hip and buttock is likely related to enthesitis, and managing the pain associated with enthesitis typically requires a longer duration of treatment.
I recommend that in addition to medication, you should also engage in more physical activity.
(2) I have been taking two tablets of Celecoxib along with one tablet of Hyaluronic Acid for two weeks, which has significantly improved my lower back pain, but there has been no improvement in my ankle and hip issues.
The rehabilitation clinic has suggested injection therapies like prolotherapy with glucose; would that be suitable? --> I personally believe the effectiveness may be limited, but since the pain could also be related to tendon or ligament injuries, it might be worth trying prolotherapy.
(3) Can X-rays or CT scans differentiate whether sacroiliitis is due to chronic inflammation or injury? I have read online that sacroiliitis seems to be quite common.
My pain points, aside from my lower back and buttocks, shift bilaterally, while my ankle and hip pain are on the right side.
Over the past year, I have had blood tests three times, and both ESR and CRP levels have been normal.
I genuinely suspect that improper long-term exercise may have caused sacroiliac joint misalignment.
Could I try massage therapy for realignment? --> An MRI would provide a more accurate assessment, and I recommend discussing this with your physician.
Inflammation caused by exercise has its own specific manifestations and should be distinguishable from sacroiliac inflammation.
If there is no adhesion in the lumbar spine and sacroiliac joint, you may be able to undergo massage therapy for realignment.
Please discuss your current spinal adhesion status with your physician and whether you can accept realignment therapy.
Additionally, it is important to repeatedly inform your physical therapist about your spinal condition and ask them to pay close attention.

Best regards from the Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare.

Reply Date: 2024/05/22

More Info


Sacroiliitis, characterized by inflammation of the sacroiliac joints, can be a challenging condition to diagnose and manage, especially when considering the potential underlying causes such as ankylosing spondylitis (AS) or other inflammatory arthritis. Your situation, with a history of back pain, peripheral arthritis, and positive HLA-B27, suggests a possible inflammatory etiology, which your physician is rightly investigating further with imaging studies like X-rays and CT scans.

1. Symptoms and Differential Diagnosis: The symptoms you describe in your right ankle and hip, such as the intermittent sharp pain and discomfort, could indeed be related to enthesitis, which is inflammation at the site where tendons or ligaments attach to bone. This is common in conditions like AS. The absence of redness, swelling, or warmth does not rule out inflammation, as some forms of enthesitis can present without these classic signs. The fact that your pain worsens with certain activities and improves with rest aligns with inflammatory pain patterns.

2. Current Treatment and Rehabilitation Options: You mentioned that your current medication regimen (two Salazopyrin and one Celebrex) has significantly improved your back pain but has not alleviated the discomfort in your ankle and hip. This is not uncommon, as different joints may respond variably to treatment. The use of physical therapy modalities like ultrasound and shortwave diathermy can be beneficial, but if these treatments exacerbate your pain, it may be worth discussing alternative therapies with your physical therapist or rheumatologist. Regarding the injection of glucose or other proliferative therapies, these can sometimes provide relief for chronic pain conditions, but their efficacy can vary, and they are typically considered when conservative measures fail.

3. Role of Imaging in Diagnosis: X-rays and CT scans can provide valuable information in differentiating between chronic inflammatory changes and acute injuries. X-rays can show changes in the sacroiliac joints, such as erosions or sclerosis, which are indicative of chronic inflammation. CT scans offer a more detailed view and can help identify subtle changes that X-rays might miss. However, while imaging can suggest the presence of inflammation, it cannot definitively distinguish between inflammation due to chronic disease (like AS) versus acute injury. The clinical context, including your symptoms and laboratory findings, plays a crucial role in this differentiation.

4. Concerns About Long-Term Effects and Management: Your concerns about the potential for long-term damage from imaging studies are valid but should be put into perspective. The radiation exposure from a CT scan is relatively low, especially when weighed against the benefits of obtaining a clear diagnosis that can guide treatment. It is essential to communicate any anxieties about imaging or treatment with your healthcare provider, as they can help address these concerns and adjust your management plan accordingly.

5. Physical Therapy and Manual Therapy: You mentioned the possibility of massage or manual therapy for your condition. While these therapies can provide symptomatic relief for some patients, they should be approached cautiously, especially in the context of inflammatory arthritis. It is advisable to consult with your healthcare provider before starting any new treatment modalities to ensure they are appropriate for your specific condition.

In summary, your symptoms and imaging findings warrant careful evaluation and management. It is crucial to maintain open communication with your healthcare team, as they can help tailor your treatment plan based on your evolving symptoms and response to therapy. Regular follow-ups and possibly further imaging or laboratory tests may be necessary to monitor your condition and adjust your treatment as needed.

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