Do Antibiotics Affect the Effectiveness of Birth Control Pills? - Obstetrics and Gynecology

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Do antibiotics affect the effectiveness of birth control pills?


Due to a burn, the doctor prescribed DEPYRETIN for inflammation and pain relief, and CEFALEXIN tablets as an antibiotic, to be taken four times a day: morning, noon, evening, and before bed.
The anti-inflammatory medication has been taken for a week, and the antibiotic has been taken for 12 days and should continue.
Online information suggests that antibiotics can affect the efficacy of birth control pills.
I have been taking the YAZ birth control pill for several months, and I take the antibiotic two hours before the pill at bedtime.
Can I engage in sexual activity while taking the antibiotic? Is there a risk of pregnancy? How many days after finishing the antibiotic should I wait before having sexual intercourse? We always use condoms, but I am concerned about other actions where my boyfriend might touch my private areas after self-secretion.
Thank you.

Niming, 20~29 year old female. Ask Date: 2024/06/02

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it generally does not have an impact.
Wishing you good health.

Reply Date: 2024/06/02

More Info


When it comes to the interaction between antibiotics and birth control pills, there is a common concern among women regarding the effectiveness of hormonal contraceptives when taking antibiotics. The primary antibiotic that has been shown to potentially interfere with the effectiveness of birth control pills is rifampin, which is used to treat tuberculosis and some other infections. However, most other antibiotics, including cephalexin, do not have a significant impact on the effectiveness of birth control pills.

In your case, you are taking cephalexin, which is a type of cephalosporin antibiotic. Current medical literature suggests that cephalexin does not reduce the effectiveness of hormonal contraceptives. Therefore, as long as you are taking your birth control pill consistently and correctly, you should still be protected against pregnancy, even while on cephalexin.

You mentioned that you are taking the antibiotic and the birth control pill at different times of the day, which is a good practice. Taking the antibiotic two hours before your birth control pill should not affect the absorption or effectiveness of the contraceptive. It is also important to continue using condoms as an additional method of protection, especially if you have concerns about potential interactions or if you are engaging in sexual activities that may involve exposure to bodily fluids.

Regarding your question about whether you can have sexual intercourse while on antibiotics, the answer is yes, you can. Since cephalexin does not interfere with the effectiveness of your birth control pills, you can engage in sexual activity without worrying about an increased risk of pregnancy, provided you are taking your contraceptive as directed. However, it is always wise to communicate with your partner about your concerns and to use condoms to further reduce any risk of sexually transmitted infections (STIs) or unintended pregnancy.

If you are still concerned about the possibility of pregnancy or the effectiveness of your birth control, it may be beneficial to consult with your healthcare provider. They can provide personalized advice based on your medical history and current medications. Additionally, if you experience any unusual symptoms or side effects while taking the antibiotics or birth control pills, it is important to seek medical advice.

In summary, while there is a general concern about antibiotics affecting birth control pills, cephalexin is not one of the antibiotics that significantly impacts their effectiveness. You can continue to have sexual intercourse while taking the antibiotic, but using condoms is a good practice for added protection. Always consult your healthcare provider if you have any doubts or concerns regarding your medications and sexual health.

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