Tongue Pain: Could It Be Related to Behçet's Disease? - Otolaryngology

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Tongue ulcer


Hello Doctor: My mother has Behçet's disease, so I pay close attention to my own health.
Recently, I have noticed that my tongue often hurts, with a swelling pain similar to when I have a sore on my tongue.
The pain occurs on both sides, usually along the edges of the top and bottom of my tongue, but I often do not see any visible sores.
Typically, the pain resolves completely within a day or two.
This afternoon, I noticed pain on the edges of my tongue again; it does not look like the white sores of an ulcer, just slightly red.
A couple of days ago, I had cold symptoms and saw a doctor who prescribed medication.
I have carefully observed my lifestyle habits, and I find that this sensation or tongue pain often occurs after staying up late for three consecutive nights until one or two in the morning.
When I get enough sleep that night and apply an oral ointment before bed, the pain usually resolves in two or three days.
I would like to ask if this could be related to Behçet's disease? Should I get tested for this? I had a genetic test done two or three years ago, and there were no abnormalities at that time.
Also, does this swelling pain in my tongue qualify as an oral ulcer?

Zhu, 20~29 year old female. Ask Date: 2024/06/11

Dr. Zheng Jueyi reply Otolaryngology


Hello, a swollen and painful tongue is often related to inflammation.
If there are no obvious wounds and it hasn't reached the level of an ulcer, you can observe it for improvement.
If the ulcer improves within a week, self-monitoring is sufficient.
However, if it persists for more than a week or does not improve, it is advisable to seek medical attention for further evaluation.

Reply Date: 2024/06/11

More Info


Tongue pain can be a distressing symptom, especially when you have a family history of Behçet's disease, which is an autoimmune condition characterized by recurrent oral and genital ulcers, skin lesions, and ocular inflammation. Given your mother's diagnosis, it is understandable that you are concerned about your own symptoms.

From your description, it seems that your tongue pain manifests as a swelling or soreness along the edges of your tongue, without visible ulcers or lesions. The pain resolves within a few days, which is a positive sign, as persistent or recurrent pain could indicate a more serious underlying condition. The fact that your symptoms seem to correlate with periods of sleep deprivation suggests that stress and fatigue may be contributing factors.
Behçet's disease can indeed cause oral ulcers, but these typically present as painful sores that are clearly visible and can take longer to heal. Your symptoms, characterized by transient pain without clear ulceration, may not fit the classic presentation of Behçet's. However, it is essential to consider that Behçet's can present variably, and some individuals may experience atypical symptoms.

The red areas you observe on your tongue could indicate inflammation, which might be due to several factors, including:
1. Oral Hygiene: Poor oral hygiene can lead to irritation and inflammation of the tongue.

2. Dietary Factors: Certain foods, especially spicy or acidic ones, can irritate the tongue.

3. Stress and Fatigue: As you noted, lack of sleep can exacerbate symptoms of various conditions, including autoimmune diseases.

4. Infections: Viral infections, such as those causing cold symptoms, can also lead to temporary tongue pain.

Regarding your question about whether this could be related to Behçet's disease, it is advisable to consult with a healthcare professional, particularly a rheumatologist or an oral medicine specialist, who can evaluate your symptoms in the context of your family history. They may recommend further tests, such as blood tests or imaging, to rule out other conditions.

As for whether your tongue pain qualifies as oral ulcers, it seems more likely that you are experiencing a form of glossitis or localized inflammation rather than classic oral ulcers. Oral ulcers are typically defined as painful lesions that can be seen and are often associated with conditions like aphthous stomatitis, which is common and usually self-limiting.

In summary, while your symptoms may not directly indicate Behçet's disease, it is essential to monitor them closely, especially given your family history. Maintaining good oral hygiene, managing stress, and ensuring adequate sleep can help alleviate your symptoms. If the pain persists or worsens, or if you develop additional symptoms, seeking medical advice is crucial for proper diagnosis and management.

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