Nystatin for Candida Infections: Is It an Antibiotic? - Obstetrics and Gynecology

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Candida medications


Today, I visited the obstetrics and gynecology department, and the doctor diagnosed me with a mild Candida infection.
He prescribed oral nystatin capsules.
Is this medication an antibiotic? I regularly take vaginal probiotics; will taking these two together reduce the effectiveness of the probiotics? I've heard that antibiotics kill both good and bad bacteria, so taking probiotics while on antibiotics is ineffective.
Is this statement correct?

W, 20~29 year old female. Ask Date: 2024/07/02

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, generally it does not have an impact.
Wishing you good health.

Reply Date: 2024/07/02

More Info


Nystatin is an antifungal medication primarily used to treat infections caused by Candida species, which are a type of yeast. It is important to clarify that Nystatin is not classified as an antibiotic. Antibiotics are designed to target and kill bacteria, while Nystatin specifically targets fungi. This distinction is crucial because the mechanisms of action and the types of infections they treat are fundamentally different.

When your doctor prescribed Nystatin for a suspected mild Candida infection, it was likely because they identified an overgrowth of yeast that could be causing your symptoms. Nystatin works by binding to the fungal cell membrane, causing it to become permeable and ultimately leading to cell death. This makes it effective in treating fungal infections, particularly those caused by Candida, which can manifest as oral thrush, vaginal yeast infections, and skin infections.

Regarding your question about the simultaneous use of Nystatin and vaginal probiotics, it is essential to understand how these two interact. Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. They are often used to restore the natural balance of bacteria and yeast in the body, particularly after antibiotic use or during a yeast infection.

While Nystatin is not an antibiotic, it does target fungal cells. Therefore, taking Nystatin should not directly affect the efficacy of probiotics, which are primarily aimed at restoring beneficial bacteria. However, the timing of when you take these medications can be important. It is generally recommended to space out the administration of antifungals and probiotics to maximize the effectiveness of both. For example, you might take Nystatin and then wait a few hours before taking your probiotics. This approach helps ensure that the probiotics have a better chance to colonize and exert their beneficial effects without being affected by the antifungal treatment.

The concern you mentioned about antibiotics killing both good and bad bacteria is valid. Broad-spectrum antibiotics can indeed disrupt the natural microbiome, leading to side effects such as diarrhea or yeast infections. This is why probiotics are often recommended during or after a course of antibiotics. However, since Nystatin is not an antibiotic, the same principle does not apply directly.
In summary, Nystatin is an antifungal medication, not an antibiotic, and it is used specifically to treat fungal infections like those caused by Candida. You can take Nystatin while also using vaginal probiotics, but it is advisable to space them out to ensure both can work effectively. Always consult with your healthcare provider for personalized advice, especially when it comes to managing medications and supplements. They can provide guidance tailored to your specific health needs and circumstances.

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