Impact of Medications on Blood Sugar Levels: A Patient's Inquiry - Family Medicine

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Issues related to steroids and blood sugar?


Hello, doctor.
Six months ago, I measured my fasting blood sugar at a testing center, and the value was 110.
Since then, I have been controlling my diet, and my recent readings have been around 83-107.
However, I have not yet measured my HbA1c (as I was unaware that it required an additional purchase at the testing center).
I have been recording my blood sugar levels using a glucose meter that I purchased myself.
My cholesterol and blood pressure are normal, but I am overweight.

However, for the past three days, my fasting blood sugar has been between 110-127.
Three days ago, I started using a topical ointment for eczema on my hands, and I also have an eye stye for which I was prescribed oral medication and topical ointments, including "Ruan" Aishuteng tablets (500 mg of acetaminophen), ophthalmic ointment, "Youli" erythromycin capsules (500 mg), and "Payton" Fushuning eye drops.
I would like to ask if these medications could affect my blood sugar levels, as I have been eating the same foods as before, similar to the 211 meal plate (sometimes even without rice).
Prior to using these medications, my blood sugar never exceeded 110, so I wonder if there is a correlation with these drugs.
Additionally, I would like to know if there is a difference in blood sugar readings when fasting for 12 hours versus 15 hours.
Does fasting for a longer period lead to higher fasting blood sugar levels? Thank you, and I appreciate your response.

Niming, 40~49 year old female. Ask Date: 2024/07/08

Dr. Lin Zhebin reply Family Medicine


Hello: 1.
The oral medication you are using does not affect blood sugar levels, and while the topical eczema cream, eye ointment, and eye drops contain steroids, topical steroids generally do not significantly impact blood sugar.
Additionally, issues related to inflammation and infection in the body can also lead to elevated blood sugar levels.
It is recommended that you consult with a family medicine physician or a metabolic specialist.
2.
Generally speaking, the longer the fasting period, the lower the blood sugar levels; however, if the fasting period is too prolonged, the body's hormones may come into play, potentially causing blood sugar levels to rise.

Reply Date: 2024/07/08

More Info


The inquiry regarding the impact of medications on blood sugar levels is a common concern among patients managing their glucose levels, particularly those who are pre-diabetic or at risk for diabetes. Based on the information provided, it appears that the patient has been actively monitoring their blood sugar levels and has made dietary adjustments to maintain a healthier range. However, fluctuations in fasting blood sugar levels have been observed, particularly after starting certain medications.

To address the first part of your question regarding whether the medications you are using could influence your blood sugar levels, it is important to note that most topical medications, such as the ointments for eczema and the eye ointments, generally have minimal systemic absorption and are unlikely to significantly affect blood glucose levels. However, corticosteroids, even in topical forms, can sometimes lead to elevated blood sugar levels, especially if used in large amounts or over extended periods. The systemic absorption is usually low, but it is still a consideration, particularly if you are using them frequently.

Regarding the oral medications you mentioned, acetaminophen (the active ingredient in "瑞安"愛舒疼錠) is not known to have a direct impact on blood glucose levels. However, it is essential to consider that any underlying inflammation or infection, which may be treated with these medications, can lead to stress responses in the body that might elevate blood sugar levels. This is due to the release of stress hormones such as cortisol, which can increase glucose production in the liver.

As for the question about fasting duration and its impact on blood sugar readings, generally, longer fasting periods can lead to lower blood sugar levels. However, if fasting is prolonged excessively, the body may enter a state of gluconeogenesis, where it produces glucose from non-carbohydrate sources, potentially leading to higher blood sugar levels. Therefore, while a 12-hour fast is typically sufficient for accurate fasting blood sugar readings, extending it to 15 hours may not necessarily yield a significantly different result. Individual responses can vary based on metabolic health, activity levels, and other factors.

In summary, while the medications you are using are unlikely to be the primary cause of the fluctuations in your fasting blood sugar levels, it is essential to consider the overall context of your health, including any infections or inflammatory conditions you may be experiencing. It is advisable to continue monitoring your blood sugar levels, maintain a balanced diet, and consult with your healthcare provider for personalized advice and potential adjustments to your treatment plan. Regular follow-ups and possibly a more comprehensive metabolic evaluation may be warranted to ensure optimal management of your blood sugar levels and overall health.

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