Coronary Artery Spasms and Ventricular Tachycardia: Key Insights - Cardiology

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Questions related to coronary artery spasm, ventricular tachycardia, and myocardial disease (LGE)?


Dear Director He,
I have read many of your patient responses and analyses with great patience, which has encouraged me to muster the courage to inquire about my ongoing concerns regarding heart issues after seeking medical attention.
I hope you can help clarify my doubts.
1.
Medical History:
(1) Since 2014, I have experienced intermittent episodes of chest tightness or pain at night (medical consultations resulted in prescriptions for Xanax or antacids, but with no significant relief), with infrequent occurrences during the day.
(2) In 2017, while walking at night, I suddenly felt palpitations, followed by a brief episode of lightheadedness, nearly fainting.
(3) In mid-2019, while walking in the office, I suddenly experienced a blackout, almost fainting.
I managed to stay upright and noticed palpitations with a heart rate of approximately 120 to 130 bpm.
After sitting down, the palpitations persisted, and I suddenly felt severe chest pain, followed by dizziness for a few seconds and overall weakness.
(4) Since mid-2019, I have undergone continuous medical examinations, with the following results:
A.
14-day Holter monitor: Detected four consecutive ventricular premature contractions (VPCs) but did not capture the waveform during the near-fainting episode.
B.
Nuclear myocardial perfusion scan: Suspected mild hypoxia in the inferior wall.
C.
800-slice cardiac CT: Myocardial bridge in the mid-LAD, with no significant stenosis (<25%).
D.
Cardiac MRI (with contrast): Left ventricle showed late gadolinium enhancement (LGE) indicating myocardial damage.
(5) Subsequently, the physician concluded that the nighttime chest pain was likely due to "coronary artery spasm," and the near-fainting episodes were probably caused by "short episodes of ventricular tachycardia." I have been prescribed a calcium channel blocker (Diltiazem 120 mg once daily), Carvedilol 150 mg (half a tablet twice daily), Amiodarone 10 mg (half a tablet twice daily), and Amlodipine 20 mg (three times daily).
2.
It has been over four years since the near-fainting incident in 2019.
After starting medication, I no longer experience near-fainting symptoms, but I still occasionally have chest pain at night or during the day.
3.
My questions for you are:
(1) In 2022, I underwent another cardiac MRI (with contrast) at National Taiwan University, which did not reveal any LGE or other myocardial damage, unlike the previous examination at the Veterans General Hospital.
Is it medically possible for LGE to disappear after taking medications that increase blood flow? If the ventricular tachycardia that caused my near-fainting was initially due to LGE scarring in the left ventricle, and the LGE has disappeared, is there a possibility that my ventricular tachycardia has resolved?
(2) Currently, my predominant symptom is not arrhythmia but rather nighttime chest tightness.
Should the dosages of my calcium channel blocker or Amlodipine be increased? Is there room for dosage escalation?
(3) Some articles online suggest that myocardial bridges may also cause coronary artery spasms or ventricular tachycardia.
Are these claims supported by medical evidence?
I have many questions stemming from my long-standing concerns and uncertainties, which I have not been able to discuss in detail with my attending physician.
I kindly ask for your assistance.
Thank you.

PPP, 30~39 year old female. Ask Date: 2024/07/09

Dr. He Dongjin reply Cardiology


Hello, is it possible for LGE to disappear after taking medications that increase blood flow? The likelihood is low, but it is still possible for LGE to resolve.
In terms of my ventricular tachycardia, is there a chance of recovery? Theoretically, it is quite possible; myocardial bridging may also contribute to coronary artery spasm or ventricular tachycardia, although the likelihood is low, it is still a possibility.
The cause of coronary artery spasm remains unclear.
It is difficult to say definitively if you have it; it may just be a physician's speculation.
Regarding nighttime chest discomfort, should the dosage of my calcium channel blockers or coronary vasodilators be increased? You can try increasing the dosage; if the symptoms improve, then go ahead and increase it.
If the symptoms are about the same, then there may be no need to increase it further.
Have you considered gastroesophageal reflux? Please get it checked.
Changhua Hospital cares about you.

Reply Date: 2024/07/09

More Info


Understanding coronary artery spasms and ventricular tachycardia is crucial for managing heart health, especially in patients with a history of chest pain and arrhythmias. Based on your detailed medical history and the results from various cardiac evaluations, let's address your concerns systematically.

1. Coronary Artery Spasms and Ventricular Tachycardia:
Coronary artery spasms can lead to transient ischemia, which may cause chest pain (angina) and can sometimes trigger arrhythmias, including ventricular tachycardia (VT). Your history of chest pain at night and episodes of palpitations, especially with near-syncope, suggests that your heart may be experiencing episodes of ischemia due to spasms. The fact that you have been prescribed calcium channel blockers indicates that your healthcare provider is addressing these spasms, as these medications help to relax and widen blood vessels, improving blood flow to the heart muscle.

2. LGE (Late Gadolinium Enhancement):
The presence of LGE on cardiac MRI typically indicates areas of myocardial scarring or fibrosis, which can be a result of previous ischemic events. The fact that your follow-up MRI did not show LGE suggests that there may have been no significant scarring at that time. In some cases, treatment with medications that improve blood flow can lead to functional improvements in the heart muscle, but it is less common for LGE to completely disappear. However, the absence of LGE in your recent MRI could indicate that your heart muscle has healed or that the previous findings were not indicative of permanent damage.

3. Ventricular Tachycardia and Recovery:
If the episodes of VT were indeed related to previous myocardial scarring, the absence of LGE could suggest that the substrate for VT has changed, potentially reducing the risk of future episodes. However, it is essential to continue monitoring your heart rhythm, as VT can also occur due to other factors, including electrolyte imbalances or ongoing ischemia.

4. Current Symptoms and Medication Adjustment:
Regarding your current symptoms of chest pain, it is essential to communicate these to your healthcare provider. If you are experiencing recurrent chest pain, especially at night, it may be necessary to reassess your medication regimen. Calcium channel blockers and other anti-anginal medications can be adjusted based on your symptoms and tolerance. Your healthcare provider may consider increasing the dosage or adding additional medications to better manage your symptoms.

5. Myocardial Bridging and Its Implications:
Myocardial bridging, where a segment of a coronary artery runs through the heart muscle instead of on its surface, can indeed contribute to ischemia and potentially provoke spasms or arrhythmias. The literature does support the notion that myocardial bridging can be associated with coronary artery spasms, particularly during periods of increased heart rate or stress. This could explain some of your symptoms, especially if they occur during physical activity or emotional stress.

In conclusion, your case involves a complex interplay of coronary artery spasms, potential myocardial ischemia, and arrhythmias. Continuous monitoring and open communication with your healthcare provider are essential for managing your condition effectively. If your symptoms persist or worsen, further evaluation, including possible adjustments to your medication or additional diagnostic testing, may be warranted. It is crucial to maintain a proactive approach to your heart health, ensuring that you address any new or concerning symptoms promptly.

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