HPV Persistence and Cancer Risks After Treatment - Oncology

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The recurrence rate of HPV (Human Papillomavirus)?


Hello, I am a patient with HPV type 16 throat cancer who has completed chemoradiation.
My doctor has confirmed that the tumor is no longer visible.
I would like to ask the following questions:
1.
Will the HPV in my body still be transmissible? Is it a permanent carrier? Is there a chance for complete clearance?
2.
Can HPV type 16 cause cancers in other parts of the body?
3.
After completing treatment, my primary physician did not conduct any HPV testing.
Am I still a carrier of HPV? If I want to know, which specialist should I consult for testing? Is it the hematology-oncology department?
4.
After treatment, aside from using condoms during sexual intercourse, is there a high risk of transmission if my partner performs oral sex without protection?
5.
I have recently developed oral mucosal ulcers, and my family member had a tooth extraction.
Is there a possibility of transmitting the virus to family members who share food?
6.
Do I need to receive the HPV vaccine again? There is very little health education information available on this topic in Taiwan.
Thank you for your response.

Cai Xiansheng, 50~59 year old female. Ask Date: 2024/07/15

Dr. Hu Ziren reply Oncology


1.
P16 is just one type of protein expression associated with HPV infection, and its significance in head and neck cancer is that patients who are P16 positive tend to have a better prognosis (for example, they respond better to chemoradiation compared to other causes such as smoking).
2.
Being P16 positive does not equate to being HPV DNA positive; in other words, HPV DNA testing is necessary to confirm whether the virus is present in the body.
Other questions can be discussed with your attending physician.
3.
Infection with HPV type 16 can also increase the risk of cancers in the reproductive and urinary tracts (such as anal cancer, penile cancer, etc.).
4.
Oral mucosal ulcers are not contagious among family members, even if one family member has had a tooth extraction.
PS: For questions regarding the HPV vaccine, safe sexual practices, and the transmission of HPV through sexual activity, it is advisable to consult an infectious disease specialist.

Reply Date: 2024/07/15

More Info


Hello, thank you for your questions regarding HPV and its implications after treatment. It’s important to address these concerns as they relate to your health and well-being.

1. HPV Persistence and Transmission: After treatment for HPV-related cancer, such as your case with HPV type 16, it is possible that the virus may still be present in your body. HPV can remain dormant in the body, and while many individuals can clear the virus naturally, some may retain it for an extended period. The likelihood of being a permanent carrier varies among individuals. Studies suggest that about 70-90% of HPV infections are cleared by the immune system within two years. However, certain high-risk types, like HPV 16, can persist and may lead to further complications. Therefore, it is essential to have regular follow-ups with your healthcare provider to monitor your HPV status.

2. Cancer Risks from HPV Type 16: HPV type 16 is known to be one of the most oncogenic strains, meaning it has a high potential to cause cancer. While you have already experienced HPV-related cancer in the throat, this strain can also lead to cancers in other areas, including the cervix, anus, vulva, vagina, and penis. It is crucial to remain vigilant and undergo regular screenings as recommended by your healthcare provider to catch any potential developments early.

3. HPV Testing After Treatment: After completing treatment, it is advisable to have follow-up HPV testing to determine if the virus is still present. If your treating physician has not scheduled this, you should discuss it with them. Typically, an otolaryngologist (ENT specialist) or a medical oncologist would be appropriate for follow-up care regarding HPV-related cancers. They can guide you on the necessity of HPV testing and any other relevant evaluations.

4. Transmission Risks Post-Treatment: Regarding sexual activity, using protection such as condoms can significantly reduce the risk of transmitting HPV to a partner. However, it is important to note that HPV can still be transmitted through skin-to-skin contact, even with condom use. If oral sex is performed without a condom, there is a risk of transmission, particularly if the virus is still present in your oral cavity. Discussing these risks openly with your partner is essential for mutual understanding and safety.

5. Oral Ulcers and Family Transmission: If you have oral mucosal ulcers, the risk of transmitting HPV to family members through shared eating utensils or food is considered low. HPV is primarily transmitted through direct skin-to-skin contact, particularly during sexual activities. However, maintaining good hygiene practices is always advisable, especially if you have open sores or ulcers.

6. HPV Vaccination: The HPV vaccine is designed to prevent infection from certain strains of the virus, including types 16 and 18, which are associated with cancer. If you have already been diagnosed with HPV-related cancer, the vaccine will not treat existing infections but may still provide protection against other HPV types. It is worth discussing with your healthcare provider whether receiving the vaccine is appropriate for you, considering your medical history and current health status.

In conclusion, it is crucial to maintain open communication with your healthcare team, adhere to follow-up appointments, and engage in preventive measures to manage your health effectively. If you have further questions or concerns, do not hesitate to reach out to your healthcare provider for personalized advice and support.

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