Colorectal Cancer with Liver Metastasis in Elderly Patients - Gastroenterology and Hepatology

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Malignant tumor of the transverse colon with multiple liver metastases?


Hello, my father is 83 years old and recently underwent a right hemicolectomy and liver biopsy due to a malignant colon tumor.
The physician indicated that the postoperative pathology report shows that the malignancy has metastasized to the liver, with small, radiating lesions occupying approximately one-quarter to one-third of the total liver area.
He has recovered his appetite post-surgery, but his weight remains low, and the doctor advised him to eat more.
I would like to ask the physician the following: 1.
Given my father's current condition, what is his expected survival time? What types of treatments can he undergo in the future? 2.
Considering my father's advanced age and his inability to endure the hardships of treatment, are there any other more palliative treatment options available to help him live more comfortably for the remainder of his life? Thank you!

fangjojo, 30~39 year old female. Ask Date: 2004/08/12

Dr. Chen Zhiping reply Gastroenterology and Hepatology


Response: Hello, colon cancer with liver metastasis is classified as stage IV colon cancer, with an average survival of about six months to one year.
Post-surgery, chemotherapy (either intravenous or oral) may be acceptable, or hepatic artery embolization could be attempted.
Currently, the chemotherapy agents available have manageable toxicity and there are effective medications to control side effects, so it should be worth trying.
Sincerely, Dr.
Chen Zhiping.

Reply Date: 2004/08/12

More Info


Understanding colorectal cancer with liver metastasis in elderly patients is a complex issue that requires careful consideration of various factors, including the patient's overall health, the extent of the disease, and the potential benefits and burdens of treatment options.

Firstly, it is important to recognize that colorectal cancer with liver metastasis is a serious condition, especially in elderly patients. The prognosis can vary widely based on several factors, including the patient's age, overall health, the extent of the metastasis, and how well the cancer responds to treatment. In your father's case, given that he is 83 years old and has undergone surgery for a malignant tumor with liver metastasis, it is crucial to have a frank discussion with his healthcare team about his prognosis. While it is difficult to predict exact survival times, the presence of liver metastasis generally indicates a more advanced stage of cancer, which can significantly impact life expectancy.
Regarding treatment options, there are several approaches that can be considered. For elderly patients, especially those who may not tolerate aggressive treatments well, a more conservative approach may be appropriate. This could include:
1. Palliative Care: This approach focuses on improving the quality of life for patients with serious illnesses. It involves managing symptoms such as pain, nausea, and fatigue, and providing psychological and emotional support. Palliative care can be provided alongside curative treatments or as the main focus of care.

2. Targeted Therapy: Depending on the specific characteristics of the tumor, targeted therapies may be an option. These treatments aim to target specific pathways involved in cancer growth and can sometimes be less harsh than traditional chemotherapy.

3. Oral Chemotherapy: Some oral chemotherapy agents may be better tolerated by elderly patients compared to intravenous options. These can be taken at home and may have a different side effect profile.

4. Observation: In some cases, if the cancer is not causing significant symptoms, a "watchful waiting" approach may be considered. This involves regular monitoring without immediate treatment, allowing the patient to maintain a better quality of life.

5. Nutritional Support: Since your father is experiencing weight loss, nutritional support is crucial. A dietitian can help create a meal plan that meets his needs and preferences, potentially including high-calorie supplements to help him regain weight.

Regarding the question of whether to pursue aggressive treatment or to consider a more passive approach, it is essential to weigh the potential benefits against the risks and burdens of treatment. Many elderly patients may prefer to focus on comfort and quality of life rather than aggressive interventions that could lead to significant side effects and hospitalizations.

In conclusion, the decision-making process should involve open communication with your father's healthcare team, including oncologists and palliative care specialists. They can provide guidance tailored to his specific situation, helping to ensure that any treatment plan aligns with his values and goals for care. It is also important to involve your father in these discussions, as his preferences and wishes should guide the treatment approach.

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