Elevated Liver Enzymes: G.O.T and G.P.T Explained - Gastroenterology and Hepatology

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Liver enzymes G.O.T (Glutamate Oxaloacetate Transaminase) and G.P.T (Glutamate Pyruvate Transaminase


Hello, I have been feeling fatigued frequently and have a bitter taste in my mouth.
My sister, who is a pharmacist, suggested that I get my liver function checked.
After the tests, my G.O.T was 74.4 (normal range 0-40) and my G.P.T was 154.6 (normal range 0-42), both significantly elevated.
The doctor recommended that I go to a larger hospital for an ultrasound examination.
I would like to ask the doctor if these values are considered very high.
Thank you.

Zhuang Xiansheng, 20~29 year old female. Ask Date: 2004/10/02

Dr. Chen Zhiping reply Gastroenterology and Hepatology


Hello, the normal range for liver enzymes GOT and GPT is generally below 40.
Your GPT level of 154 is approximately 3 to 4 times elevated, which is not extremely high, but it is important to understand the underlying cause (such as whether there is hepatitis B or C, or fatty liver).
Regular monitoring is necessary (blood tests every 3 months), and an abdominal ultrasound is also recommended.
Please visit a regional or higher-level hospital's hepatobiliary and gastroenterology department, where they should be able to provide ultrasound examinations.
Thank you!

Reply Date: 2004/10/02

More Info


Elevated liver enzymes, specifically G.O.T (AST) and G.P.T (ALT), can be indicative of various underlying liver conditions. In your case, the results show G.O.T at 74.4 (normal range: 0-40) and G.P.T at 154.6 (normal range: 0-42). These values are significantly above the normal range, suggesting that there may be some liver dysfunction or damage.

G.O.T (also known as AST) and G.P.T (also known as ALT) are enzymes that are primarily found in the liver. When liver cells are damaged, these enzymes are released into the bloodstream, leading to elevated levels. While both enzymes are used to assess liver health, ALT is more specific to the liver, whereas AST can also be elevated in conditions affecting other organs, such as the heart or muscles.

Your symptoms of fatigue and a bitter taste in your mouth could be related to liver dysfunction. Fatigue is a common symptom in individuals with liver issues, as the liver plays a crucial role in detoxifying the blood and metabolizing nutrients. A bitter taste may also be associated with liver problems, as it can be a sign of bile acid accumulation or other digestive disturbances.

Given the significant elevation of your liver enzymes, it is essential to follow your doctor's recommendation for further evaluation, including an ultrasound of the liver. This imaging study can help identify structural abnormalities, such as fatty liver disease, cirrhosis, or tumors. Additionally, your healthcare provider may recommend further blood tests to check for viral hepatitis (such as Hepatitis B and C), autoimmune liver diseases, or other conditions that could be contributing to your elevated enzyme levels.

It is also important to consider lifestyle factors that may be impacting your liver health. Maintaining a healthy weight, avoiding excessive alcohol consumption, and being cautious with medications and supplements are crucial steps in supporting liver function. If you have any underlying conditions, such as diabetes or high cholesterol, managing those effectively can also help protect your liver.

In summary, your elevated G.O.T and G.P.T levels are concerning and warrant further investigation. It is crucial to work closely with your healthcare provider to determine the underlying cause of these elevations and to develop an appropriate management plan. Regular monitoring of liver enzymes and following up with imaging studies will be essential in understanding your liver health and preventing potential complications.

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