Is It Normal to Taste Eye Drops? Safety Concerns Explained - Ophthalmology

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Did eye drops get into the mouth?


I have chronic conjunctivitis, and my ophthalmologist removed a stone and prescribed eye drops for me.
Shortly after using the eye drops at home, I noticed a bitter taste in my mouth, similar to taking an oral medication.
Is this a normal phenomenon? Are there safety concerns if the eye drops are ingested? The medications I am using are Santen, Refresh, and chloramphenicol.
Thank you for your response.

Mr. Hei, 30~39 year old female. Ask Date: 2004/10/05

Dr. Cai Jingyao reply Ophthalmology


Eye drops can travel through the nasolacrimal duct to the nasal cavity and into the throat, which may cause a sensation in the mouth.
After administering the drops, gently press the inner corner of the eyelid for one minute to prevent the medication from entering the mouth.
Ingesting eye drops typically involves a very small amount and is generally not a safety concern; however, it is advisable to avoid swallowing glaucoma eye drops and to use them with caution.

Reply Date: 2004/10/05

More Info


It is not uncommon for patients to experience a bitter taste in their mouth after using eye drops, especially if the drops are not applied correctly. This phenomenon can occur due to the drainage of the medication from the eye into the nasolacrimal duct, which connects the eyes to the nasal cavity. When the drops drain into the nasal cavity, they can stimulate taste receptors, leading to a bitter or unusual taste in the mouth.
In your case, you mentioned that you are using eye drops prescribed for chronic conjunctivitis, specifically those containing sodium hyaluronate, artificial tears, and chloramphenicol. While these medications are generally safe when used as directed, it is important to ensure that you are applying them correctly to minimize the risk of systemic absorption and unwanted side effects.

Here are some safety concerns and recommendations regarding the use of eye drops:
1. Proper Application: To minimize the risk of the medication draining into your throat and causing an unpleasant taste, it is advisable to apply the drops while tilting your head back slightly. After applying the drops, you can close your eyes and gently press on the inner corner of your eye (the punctum) for about 30 seconds. This technique helps to block the drainage of the drops into the nasolacrimal duct, reducing the likelihood of tasting the medication.

2. Systemic Absorption: While most eye drops are designed for local action, some medications can be absorbed systemically, especially if used in large quantities or over extended periods. Chloramphenicol, for instance, is an antibiotic that can have systemic effects if absorbed in significant amounts. However, when used as directed for eye conditions, the risk of serious systemic side effects is low.

3. Bitter Taste: The bitter taste you are experiencing is likely due to the chloramphenicol or other components in the eye drops. While it is generally not harmful, if the taste persists or is accompanied by other symptoms (such as nausea, vomiting, or unusual reactions), you should consult your healthcare provider.

4. Follow-Up: Given that you are dealing with chronic conjunctivitis, it is essential to have regular follow-ups with your eye care professional. They can monitor your condition and adjust your treatment plan as necessary. If you have concerns about the eye drops or if your symptoms worsen, do not hesitate to reach out to your doctor.

5. Potential Side Effects: While chloramphenicol is effective for treating bacterial infections, it can cause side effects in some individuals. Common side effects include irritation, redness, or a burning sensation in the eyes. If you experience severe discomfort, changes in vision, or signs of an allergic reaction (such as swelling or rash), seek medical attention promptly.

In summary, experiencing a bitter taste after using eye drops can be a normal occurrence, but it is essential to apply the drops correctly to minimize this effect. Always follow your healthcare provider's instructions regarding the use of eye medications, and do not hesitate to reach out to them with any concerns or questions about your treatment. Regular monitoring and communication with your eye care professional will help ensure the best outcomes for your eye health.

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