Growth Hormone Treatment for Your 11-Year-Old Daughter - Pediatrics

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Growing taller


My daughter is 11 years and 6 months old and is 145 cm tall.
She started her menstrual cycle in February.
I would like to know how much more she can grow.
We consulted an endocrinologist, who suggested that we consider growth hormone therapy.
What is the effectiveness of this treatment, and are there any side effects? The doctor recommended this after taking an X-ray of her growth plates.

peng, 40~49 year old female. Ask Date: 2001/04/25

Dr. Zhao Yongkang reply Pediatrics


A: An 11-year and 6-month-old girl has just started menstruating and still has the potential for growth.
Her height is significantly shorter compared to peers of the same age, with no specific reasons such as genetic factors, malnutrition, or major illnesses.
An X-ray of the growth plates shows they are not yet closed, and further examination confirms a deficiency in growth hormone.
Administering growth hormone would be effective and is covered by health insurance.
Please schedule an appointment with the pediatric endocrinology specialist, Dr.
Niu Daoming, on Thursday, May 10th, in the afternoon.
Thank you for your inquiry.
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Reply Date: 2001/04/25

More Info


When considering growth hormone treatment for your 11-year-old daughter, it's essential to understand both the potential benefits and risks associated with this therapy. At 145 cm tall and having started menstruation at 11 years and 6 months, your daughter is at a critical juncture in her growth and development.
Growth Potential and Hormonal Influence
At this age, girls typically experience a growth spurt during puberty, which can last for several years. However, the onset of menstruation often indicates that the growth plates in the bones are beginning to close, which can limit future height potential. The growth plates, or epiphyseal plates, are areas of developing cartilage tissue near the ends of long bones. Once these plates close, further growth in height is no longer possible.
The fact that your daughter has had an X-ray to assess her growth plates is a positive step. If the growth plates are still open, there may still be some potential for growth. However, if they are already closed or nearing closure, the opportunity for significant height increase diminishes.

Growth Hormone Treatment
Growth hormone (GH) therapy can be effective in certain situations, particularly for children diagnosed with growth hormone deficiency or specific conditions that impair growth. In your daughter's case, if her growth potential is limited due to early onset of menstruation and the associated closure of growth plates, the effectiveness of GH treatment may be reduced.
The treatment involves regular injections of synthetic growth hormone, which can stimulate growth in children who have a deficiency or specific medical conditions. The expected outcomes can vary widely based on individual circumstances, including the underlying cause of short stature, the timing of treatment, and adherence to the regimen.

Potential Side Effects
While GH therapy can be beneficial, it is not without risks. Common side effects may include:
1. Injection Site Reactions: Pain, swelling, or redness at the injection site.

2. Headaches: Some children may experience headaches during treatment.

3. Joint Pain: Discomfort in the joints can occur, particularly as the body adjusts to the hormone.

4. Increased Risk of Diabetes: GH can affect insulin sensitivity, potentially leading to glucose metabolism issues.

5. Fluid Retention: Some children may experience swelling due to fluid retention.

It's crucial to have a thorough discussion with your healthcare provider about these potential side effects and how they may impact your daughter's overall health and well-being. Regular monitoring during treatment is essential to manage any adverse effects and to assess the effectiveness of the therapy.

Consultation with Specialists
Given the complexity of growth issues and the potential implications of hormone therapy, it is advisable to consult with a pediatric endocrinologist who specializes in growth disorders. They can provide a comprehensive evaluation of your daughter's growth potential, including her bone age, growth patterns, and any underlying health issues that may affect her growth.

In conclusion, while growth hormone treatment can be a viable option for some children, it is essential to weigh the potential benefits against the risks and to consider your daughter's individual circumstances. Open communication with your healthcare provider will help you make an informed decision that prioritizes her health and development.

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