Synovial Tumors: Symptoms, Treatment, and Prognosis - Orthopedics

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Synovial tumor


Hello, I would like to ask about my condition.
I started experiencing severe pain in my knee in 1999 due to something getting stuck inside.
X-rays showed normal results.
By 2000, I began to have swelling, and the fluid extracted was bloody.
After undergoing arthroscopy, small fragments of bone were removed.
Three months later, the swelling returned, so I had another arthroscopy in 2001, which revealed a tumor.
Six months after that procedure, the swelling returned again, leading to a third arthroscopy in 2002, where another tumor was found, and part of the bone with synovial hyperplasia was removed.
By the end of this year, the swelling returned, and after another arthroscopy, the entire synovial membrane was found to be tumor-infiltrated.
The doctor informed me that arthroscopy could not address the issue, and I would need an open surgery to remove the entire synovial membrane.
I was told that this condition is medically termed as pigmented villonodular synovitis (PVNS).
I would like to know if this type of tumor is benign or malignant.
If it is benign, is there a possibility it could turn malignant? What are the causes of this condition? Is it curable? Honestly, I am exhausted from the endless surgeries.
Thank you for your assistance.

Yan Juan Yong Wu Zhi Jing Shou Shu De Ren, 20~29 year old female. Ask Date: 2004/12/10

Dr. Li Wenlin reply Orthopedics


Hello: In response to your question...
based on your description, you are most likely suffering from pigmented villonodular synovitis (PVNS), which is a benign tumor characterized by a tendency to recur.
Pathologically, it may be derived from fibroblasts or macrophages, and the likelihood of malignant transformation is low.
However, it is bothersome due to its high recurrence rate (approximately one-third).
If the lesion is well-defined and solitary, arthroscopic surgery is the best option, provided that it can be completely excised.
However, in cases of diffuse lesions or those that have recurred, a complete synovectomy of the knee may be the only viable choice.
Postoperative rehabilitation is also essential.
Keelung Hospital, Department of Health, Executive Yuan, Li Wen-Lin.

Reply Date: 2004/12/10

More Info


Synovial tumors, particularly those that arise in the knee joint, can be a source of significant discomfort and concern for patients. Based on your description, it appears that you have been experiencing a chronic issue with your knee, characterized by recurrent swelling, pain, and the presence of tumors that have necessitated multiple arthroscopic surgeries.

Understanding Synovial Tumors
Synovial tumors can be classified into several types, including benign and malignant forms. The most common benign synovial tumors are synovial sarcomas and pigmented villonodular synovitis (PVNS). PVNS is a condition that can cause the synovial membrane to thicken and form nodules, leading to joint swelling and pain. It is important to note that while PVNS is generally considered benign, it can be aggressive locally and may recur after treatment.

In your case, the term "pigmented tumor" suggests that you might be dealing with PVNS, which is characterized by the presence of hemosiderin (a pigment derived from blood) within the tumor. This condition can lead to joint damage over time if not adequately treated.


Symptoms
The symptoms of synovial tumors typically include:
- Joint pain and swelling
- Limited range of motion
- Recurrent joint effusions (fluid accumulation)
- Symptoms may worsen with activity

Diagnosis
Diagnosis is usually made through imaging studies such as MRI, which can provide detailed information about the tumor's size, location, and effect on surrounding structures. A biopsy may also be necessary to confirm the diagnosis and to determine whether the tumor is benign or malignant.


Treatment
Treatment for synovial tumors often involves surgical intervention. In cases of PVNS, the goal is to remove the affected synovial tissue completely. This can sometimes be achieved through arthroscopy, but in more extensive cases, an open surgical approach may be required, as your doctor has suggested.
- Surgical Options:
- Arthroscopic Debridement: Minimally invasive removal of tumor tissue.

- Open Synovectomy: Complete removal of the synovial membrane if the tumor is extensive.

- Adjuvant Therapy: In some cases, additional treatments such as radiation therapy may be considered, especially if there is a risk of recurrence or if the tumor is malignant.


Prognosis
The prognosis for synovial tumors varies depending on the type and extent of the tumor. Benign tumors like PVNS can often be managed effectively, but they have a tendency to recur, necessitating ongoing monitoring and possibly additional surgeries.
- Recurrence: Even after surgical removal, PVNS can recur, and patients may require multiple surgeries over time. The recurrence rate can be significant, and some studies suggest that complete synovectomy can reduce the risk of recurrence.

- Malignant Potential: While benign tumors like PVNS are not cancerous, there is a small risk that they could transform into a malignant form, particularly if left untreated for a long time. Regular follow-up with your healthcare provider is crucial to monitor for any changes.


Causes
The exact cause of synovial tumors, particularly PVNS, is not well understood. Some theories suggest that they may be related to trauma or chronic irritation of the joint, but definitive causes remain elusive.


Conclusion
It is understandable to feel frustrated with the ongoing nature of your condition and the repeated surgeries. It is essential to have open communication with your healthcare provider about your concerns and to explore all available treatment options, including potential referrals to specialists in orthopedic oncology or rheumatology who may offer additional insights or alternative treatments.

In summary, while synovial tumors can be challenging to manage, with appropriate treatment and monitoring, many patients can achieve a good quality of life. Please ensure that you continue to follow up with your healthcare team to address any new symptoms or concerns as they arise.

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