Is Metformin Safe for My Uterine Fibroids and Symptoms?

Is Metformin suitable for my condition?

I have two uterine fibroids, each measuring 3 cm.
In March of this year, I underwent a vaginal ultrasound.
During my ovulation period, specifically ten days after my menstrual period, I began experiencing some discomfort symptoms such as edema, palpitations, and lower back pain.
These symptoms have persisted for a year.
Last month, my gynecologist prescribed me to take Medroxyprogesterone (Medsyn) starting on the fifth day after my menstrual period for twenty-one days.
However, during this time, my discomfort has worsened, particularly the palpitations and breast tenderness.

Should I continue taking this medication next month? I consulted a traditional Chinese medicine practitioner who advised against taking it, stating that women over forty should avoid contraceptive pills due to an increased risk of cancer.
Is this medication a contraceptive pill, or could my symptoms be due to other underlying issues that require further examination? Please advise.

Chen, 40~49 year old female. Ask Date: 2001/04/29

Dr. Wei Fumao reply Obstetrics and Gynecology

The ingredients of this medication have been inquired about at various pharmacies in Pingtung, but none have it in stock, and its components are unknown.
If uterine fibroids are not too large or if there is a risk of significant bleeding (heavy menstrual bleeding), the general management principle is simply observation without the need for medication.
Taking Mesitran tablets, which may be similar to contraceptive pills, could also lead to discomfort.
Please discuss this with your treating physician.

Reply Date: 2001/04/29

More Info

When considering the safety of using Metformin in conjunction with hormonal contraceptives like the one you mentioned (often referred to as "Yaz" or "Yasmin"), it is important to understand both the mechanisms of these medications and their potential interactions, especially in the context of your existing health conditions, such as uterine fibroids.

Metformin is primarily used to manage insulin resistance and is commonly prescribed for conditions like polycystic ovary syndrome (PCOS). It works by improving insulin sensitivity, which can help regulate menstrual cycles and potentially aid in weight management. On the other hand, hormonal contraceptives are often prescribed to manage symptoms associated with hormonal imbalances, such as irregular periods, acne, and other symptoms related to conditions like PCOS or uterine fibroids.

In your case, the use of Metformin alongside hormonal contraceptives is generally considered safe. There are no known significant drug interactions between Metformin and most hormonal contraceptives, including the one you mentioned. This means that taking both medications together should not pose any additional risks compared to taking either medication alone. However, it is essential to monitor your symptoms closely, as individual responses to medications can vary.

Regarding your concerns about the side effects you are experiencing, such as water retention, palpitations, and breast tenderness, these symptoms can sometimes occur with hormonal contraceptives. Hormonal fluctuations can lead to various side effects, and it is not uncommon for women to experience discomfort when starting or adjusting to hormonal medications. If these symptoms are severe or persistent, it is crucial to discuss them with your healthcare provider. They may consider adjusting your dosage or switching to a different contraceptive method that may be better tolerated.

Your mention of a traditional medicine practitioner advising against hormonal contraceptives after the age of 40 due to cancer risks is a common concern. While it is true that certain hormonal therapies can carry risks, including an increased risk of certain types of cancer, the overall risk is influenced by various factors, including family history, personal health history, and the specific type of hormonal therapy used. It is essential to weigh the benefits of symptom management against these risks. Many women over 40 safely use hormonal contraceptives, especially when monitored by a healthcare provider.

If you are experiencing significant discomfort or if your symptoms are not improving, it may be worthwhile to explore other treatment options. This could include alternative contraceptive methods, lifestyle changes, or additional medical interventions for your uterine fibroids.
In summary, using Metformin alongside hormonal contraceptives is generally safe, but it is essential to monitor your symptoms and maintain open communication with your healthcare provider. They can help you navigate your treatment options and make adjustments as necessary to ensure your health and well-being. If you have further concerns about your symptoms or the medications you are taking, do not hesitate to seek a second opinion or further evaluation from a specialist.

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