The mother had a hemoglobin level of 8.4, and the doctor recommended a blood transfusion. However, after the transfusion, she experienced a rejection reaction?
Hello Doctor: My mother has multiple pneumonia complicated by sepsis.
Her red blood cell count is only 8.4, and the doctor recommended transfusing 2 units of blood.
However, after the first unit was transfused, she experienced shaking, fever, and vomiting.
How long might these rejection symptoms last, and is there a risk to her life? Thank you for your response.
Xiao Su, 20~29 year old female. Ask Date: 2004/12/29
Dr. Tang Jieru reply Cardiology
Hello, Xiao Su: Allergic reactions caused by blood transfusions can occasionally occur, as you mentioned, with symptoms such as fever and generalized shaking.
Typically, the transfusion should be stopped immediately, and antihistamines should be administered, which usually improves the condition within 24 hours.
If the mother has a history of frequent blood transfusions, the likelihood of experiencing allergic reactions increases.
A hemoglobin level of 8.4 is not immediately dangerous unless the patient shows obvious signs of bleeding (such as melena or hematemesis); therefore, blood transfusions should be avoided whenever possible.
If transfusion is unavoidable, it should ideally be done when the patient is not febrile.
Generally, blood transfusions involve Packed Red Blood Cells (PRBC), and patients with a history of allergies may opt for special blood products such as washed red blood cells to reduce the risk of allergic reactions.
Thank you for your inquiry.
Reply Date: 2004/12/29
More Info
When a patient undergoes a blood transfusion, especially in cases of severe anemia or other critical conditions, it is crucial to monitor for any adverse reactions. In your mother's case, the symptoms of shaking, fever, and vomiting following the transfusion are concerning and may indicate an allergic reaction or a more severe transfusion reaction.
Transfusion reactions can vary in severity and type. The most common reactions include allergic reactions, febrile non-hemolytic reactions, and in rare cases, hemolytic reactions. Allergic reactions can manifest as mild symptoms like hives or itching, but they can escalate to more severe symptoms, including fever, chills, and gastrointestinal distress, as seen in your mother.
Typically, mild allergic reactions can resolve within a few hours after stopping the transfusion and administering antihistamines. However, if the reaction is more severe, such as a hemolytic reaction, it can lead to serious complications, including kidney failure or shock, which can be life-threatening. In such cases, immediate medical intervention is necessary.
Given your mother's history of low red blood cell count (RBC) at 8.4, it is essential to understand that while transfusions can be life-saving, they also carry risks. The medical team should have monitored her closely during and after the transfusion for any signs of adverse reactions. If her symptoms persist or worsen, it is critical to seek immediate medical attention.
In terms of the duration of these symptoms, if they are indeed related to a transfusion reaction, they may last from a few hours to a couple of days, depending on the severity of the reaction and the treatment provided. The medical team may administer medications to alleviate symptoms and monitor her vital signs closely.
It is also important to note that if your mother has had previous transfusions, she may be at a higher risk for developing allergic reactions due to sensitization. In such cases, pre-medication with antihistamines or corticosteroids may be considered before future transfusions to minimize the risk of reactions.
In conclusion, while your mother's symptoms are concerning, the immediate risk to her life depends on the type and severity of the reaction. It is crucial to communicate with her healthcare providers about her symptoms and ensure she receives appropriate care. If her condition does not improve or if new symptoms arise, do not hesitate to seek emergency medical assistance.
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