White Bumps at the Corner of the Mouth: Possible Skin Cancer?

White spots at the corners of the mouth?

Hello Dr.
Jiang, my mother has had white spots at the corners of her mouth for over a month.
During this time, she has seen several dermatologists who all said it was herpes or something similar and that it was not a concern.
However, yesterday my mother accidentally popped one of the blisters, and her mouth became swollen.
Today, she saw a different doctor who suggested it could possibly be a precancerous skin condition and recommended a biopsy.
I would like to ask Dr.
Jiang if this is a possibility.
The symptoms are: white spots at the corners of the mouth, slight peeling, and the lips appear very pale.
My mother also has a history of benign lipomas and seborrheic dermatitis.
Thank you.

Zi Xi, 20~29 year old female. Ask Date: 2005/02/16

Dr. Jiang Zheen reply Dermatology

I cannot answer this question without seeing you in person.
If you are very concerned, I recommend visiting a medical center for an examination.

Reply Date: 2005/02/16

More Info

The presence of white bumps or spots at the corners of the mouth can be concerning, especially when there are changes in the skin's appearance or texture. In your mother's case, the white spots have persisted for over a month, and there has been a recent incident where one of these spots was ruptured, leading to swelling. While several dermatologists initially diagnosed the condition as herpes or a benign issue, the suggestion from another physician that it could potentially be a precursor to skin cancer warrants further investigation.

White spots or bumps around the mouth can arise from various causes, including benign conditions such as Fordyce spots, which are small, painless, pale bumps that can appear on the lips and are a normal anatomical variant. Other possibilities include angular cheilitis, which is an inflammation of the corners of the mouth that can cause cracking and white patches, often due to fungal or bacterial infections. However, persistent lesions that change in appearance, especially those that bleed or become painful, should be taken seriously.

Skin cancer, particularly squamous cell carcinoma, can manifest as a persistent sore or a growth that doesn't heal. The risk factors for skin cancer include prolonged sun exposure, a history of skin cancer, and certain skin types that are more susceptible to UV damage. Given your mother's history of benign skin tumors and seborrheic dermatitis, it is essential to consider that her skin may be more vulnerable to changes.

The recommendation for a biopsy is a prudent step. A biopsy will allow for a definitive diagnosis by examining the tissue under a microscope. This can help determine whether the lesions are benign, precancerous, or malignant. If skin cancer is diagnosed, early detection is crucial for effective treatment and better outcomes.

In addition to the biopsy, it would be beneficial for your mother to maintain regular follow-ups with a dermatologist, especially if she has a history of skin issues. Keeping the affected area clean and avoiding any irritants can also help manage symptoms while awaiting further evaluation.

In summary, while the white bumps at the corners of your mother's mouth may not necessarily indicate skin cancer, the persistence of the symptoms and the recent changes warrant a thorough investigation. A biopsy is the best course of action to rule out any serious conditions. It is always better to err on the side of caution when it comes to skin changes, especially in individuals with a history of skin issues.

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