How Long After Hepatitis B Vaccination Can You Safely Conceive? - Obstetrics and Gynecology

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How long after receiving the hepatitis B vaccine should one wait before trying to conceive?


I received my second dose of the Hepatitis B vaccine on December 19th last year.
How long after the vaccination will it not affect the health of a fetus during pregnancy? Additionally, could you provide the full English name of the Hepatitis B vaccine and the dosage for each shot? I currently live in the Netherlands, and my period is about eight to nine days late, so there is a possibility that I might be pregnant.
Therefore, I plan to visit the hospital for a check-up, and my husband has asked me to gather this vaccination information for the doctor’s reference.
Thank you!

Xiong Tai Tai, 30~39 year old female. Ask Date: 2001/05/21

Dr. Wu Zongcheng reply Obstetrics and Gynecology


The vaccine used in our hospital is Engerix-B, produced by the Belgian pharmaceutical company SB Biolopicals, at a dosage of 20 mg/dose.
(1) Currently, there is insufficient data; it is unknown whether the vaccine affects the fetus during pregnancy, but it can be compared to general *inactivated virus* vaccines, which have no impact on the fetus.
(2) According to safety principles, it is the most conservative guideline to wait 3 months after receiving the hepatitis B vaccination before attempting to conceive.

Reply Date: 2001/05/21

More Info


When it comes to the timing of conception after receiving the Hepatitis B vaccination, it is essential to understand both the vaccination schedule and the implications for pregnancy. The Hepatitis B vaccine is typically administered in a series of three doses. The standard schedule is as follows:
1. First Dose: At any time.

2. Second Dose: One month after the first dose.

3. Third Dose: Six months after the first dose.

In your case, since you received your second dose on December 19, you would be due for your third dose around June 19 of the following year. The vaccine is designed to provide immunity against the Hepatitis B virus, and studies have shown that it is safe for women to conceive after completing the vaccination series.
Generally, it is recommended to wait until you have completed the full vaccination series before trying to conceive, which means waiting until after your third dose. However, if you are already pregnant or suspect you might be, it is crucial to consult with your healthcare provider. The Hepatitis B vaccine is considered safe during pregnancy, and it does not pose a risk to the fetus.
Regarding the English terminology for the Hepatitis B vaccine, it is commonly referred to as the "Hepatitis B vaccine" or "HBV vaccine." The vaccine is usually administered in the following dosages:
- First Dose: 10 mcg (for infants and children) or 20 mcg (for adults) depending on the formulation.

- Second Dose: 10 mcg or 20 mcg, administered one month after the first dose.

- Third Dose: 10 mcg or 20 mcg, administered six months after the first dose.

It is important to note that the vaccine is highly effective, with about 95% of individuals developing protective antibodies after completing the series. If you have any concerns about your vaccination status or potential pregnancy, it is advisable to seek medical advice. Your healthcare provider can perform blood tests to check for the presence of Hepatitis B antibodies and ensure that you are adequately protected.

In summary, while it is generally safe to conceive after completing the Hepatitis B vaccination series, if you suspect you might be pregnant, it is best to consult with your healthcare provider for personalized advice and to ensure both your health and the health of your potential child.

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